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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">milmed</journal-id><journal-title-group><journal-title xml:lang="ru">Военная медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Military Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-5044</issn><publisher><publisher-name>Белорусский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51922/2074-5044.2024.4.115</article-id><article-id custom-type="elpub" pub-id-type="custom">milmed-190</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДИСКУССИОННАЯ ТРИБУНА</subject></subj-group></article-categories><title-group><article-title>Патогенетическое обоснование объема операции у пациентов в зависимости от категории некротического панкреатита</article-title><trans-title-group xml:lang="en"><trans-title>PATHOGENETIC RATIONALE FOR THE VOLUME OF OPERATION IN PATIENTS DEPENDING ON THE CATEGORY OF NECROTIC PANCREATITIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белоконев</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Belokonev</surname><given-names>V. I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пушкин</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Pushkin</surname><given-names>S. Yu.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Храновский</surname><given-names>Д. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Khranovsky</surname><given-names>D. G.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Антропов</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Antropov</surname><given-names>I. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Катков</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Katkov</surname><given-names>S. S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Николаев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikolaev</surname><given-names>A. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кашкаров</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kashkarov</surname><given-names>V. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смаль</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Smal</surname><given-names>N. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мельзетдинов</surname><given-names>Р. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Melzetdinov</surname><given-names>R. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нуянзин</surname><given-names>Э. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nuyanzin</surname><given-names>E. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Матвеев</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Matveev</surname><given-names>E. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава РФ, ГБУЗ Городская клиническая больница № 1 имени Н.И. Пирогова</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>23</day><month>08</month><year>2026</year></pub-date><volume>0</volume><issue>4</issue><fpage>115</fpage><lpage>122</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Белоконев В.И., Пушкин С.Ю., Храновский Д.Г., Антропов И.В., Катков С.С., Николаев А.В., Кашкаров В.А., Смаль Н.В., Мельзетдинов Р.А., Нуянзин Э.А., Матвеев Е.В., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Белоконев В.И., Пушкин С.Ю., Храновский Д.Г., Антропов И.В., Катков С.С., Николаев А.В., Кашкаров В.А., Смаль Н.В., Мельзетдинов Р.А., Нуянзин Э.А., Матвеев Е.В.</copyright-holder><copyright-holder xml:lang="en">Belokonev V.I., Pushkin S.Y., Khranovsky D.G., Antropov I.V., Katkov S.S., Nikolaev A.V., Kashkarov V.A., Smal N.V., Melzetdinov R.A., Nuyanzin E.A., Matveev E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://milmed.ejournal.by/jour/article/view/190">https://milmed.ejournal.by/jour/article/view/190</self-uri><abstract><p>За последние 20 лет лечение НП существенно изменилось в сторону от открытого хирургического вмешательства к минимально инвазивным методам, однако летальность остается высокой и колеблется от 39 до 90 % в зависимости от развивающихся осложнений.</p><sec><title>Цель исследования</title><p>Цель исследования: обоснование выбора объема операции у пациентов в зависимости от категории некротического панкреатита.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Проведен анализ лечения 88 пациентов с острым панкреатитом тяжёлого течения. Мужчин было 49 (55,7 %), женщин – 39 (44,3 %). Средний возраст составил 57,5 лет. Из общего числа больных билиарный панкреатит был – у 45 (51,1 %), алиментарный – у 31 (35,2 %), посттравматический – у 9 (10,2 %), послеродовый – у 3 (3,4 %). При лечении больных придерживались тактики основанной на категории некротического панкреатита, который может быть паренхиматозным, перипанкреатическим, комбинированным, стерильным и инфицированным.</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. В стадию панкреатогенной токсемии по абсолютным показаниям оперировано 36 (40,9 %) пациентов, в том числе и 3 женщины с послеродовым панкреатитом, умерло 13 (36,1 %) больных. В стадию панкреатогенного инфильтрата вынужденно, по тем же показаниям и в том же объеме, было оперировано 3 (3,4 %) пациентов, умер 1 (33,3 %). В стадию гнойных осложнений оперировано 49 (55,7 %) больных, умерло 20(40,8 %). У 30(61,2 %) пациентов был инфицированный паренхиматозный панкреатит, умерло 6(20 %). У 19(38,8 %) больных с перипанкреатическим и комбинированным НП с распространением флегмоны на забрюшинное пространство по правому и левому боковым каналам и на брыжейку ободочной кишки, умерло 14(73,3 %). У 9 пациентов НП с распространенными флегмонами при частичной резекции толстой кишки и выведением проксимальной колостомы умерло 8 (88,9 %), при субтотальной колэктомии с выведением илеостомы из 10, умерло 6 (60 %).</p></sec><sec><title>Выводы</title><p>Выводы. У больных НП в стадиях панкреатогенной токсемии и инфильтрата операция необходима при по абсолютных показаниях при развитии абдоминального компартмент–синдрома, скоплениях панкреатогенного экссудата в брюшной полости и в забрюшинном пространстве при паралитической острой кишечной непроходимости (ОКН) и перитоните. При инфицированном некротическом паренхиматозном панкреатите результаты лучше при выполнении отсроченных операций при сравнении с вмешательствами в ранние сроки. При инфицированном перипанкреатическом и комбинированном некротическом панкреатите с распространением флегмоны на брыжейку ободочной кишки субтотальная колэктомия с выведением концевой колостомы позволяет получить результаты лучше, чем при резекции участка толстой кишки с выведением концевой колостомы, снижая, таким образом, летальность у пациентов с терминальной стадией заболевания.</p></sec></abstract><trans-abstract xml:lang="en"><p>Over the past 20 years, the treatment of NP has changed significantly away from open surgery to minimally invasive methods, but mortality remains high and ranges from 39 to 90 % depending on the complications that develoр.</p><sec><title>Purpose of the study</title><p>Purpose of the study: to justify the choice of the extent of surgery in patients depending on the category of necrotizing pancreatitis.</p></sec><sec><title>Material and methods</title><p>Material and methods. An analysis of the treatment of 88 patients with severe acute pancreatitis was carried out. There were 49 men (55.7 %), 39 women (44.3 %). The average age was 57.5 years. Of the total number of patients, 45 (51.1 %) had biliary pancreatitis, 31 (35.2 %) had nutritional pancreatitis, 9 (10.2 %) had posttraumatic pancreatitis, 3 (3.4 %) had postpartum pancreatitis. When treating patients, we followed a tactic based on the category of necrotizing pancreatitis, which can be parenchymal, peripancreatic, combined, sterile and infected.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. At the stage of pancreatogenic toxemia, 36 (40.9 %) patients were operated on according to absolute indications, including 3 women with postpartum pancreatitis, 13 (36.1 %) patients died. At the stage of pancreatogenic infiltrate, 3 (3.4 %) patients were forced to undergo surgery for the same indications and to the same extent, 1 (33.3 %) died. At the stage of purulent complications, 49 (55.7 %) patients were operated on, 20 (40.8 %) died. 30(61.2 %) patients had infected parenchymal pancreatitis, 6(20 %) died. In 19 (38.8 %) patients with peripancreatic and combined NP with the spread of phlegmon to the retroperitoneal space along the right and left lateral canals and to the mesentery of the colon, 14 (73.3 %) died. In 9 NP patients with widespread phlegmon, 8 (88.9 %) died during partial resection of the colon and proximal colostomy; out of 10, 6 (60 %) died during subtotal colectomy with ileostomy.In case of infected peripancreatic and combined necrotizing pancreatitis with the spread of phlegmon to the mesocolon, subtotal colectomy with end colostomy allows for better results than with resection of a section of the colon with end colostomy, thus reducing mortality in patients with end-stage disease.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>некротический панкреатит</kwd><kwd>тактика лечения</kwd><kwd>объем операций</kwd><kwd>результаты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>necrotizing pancreatitis</kwd><kwd>treatment tactics</kwd><kwd>volume of operations</kwd><kwd>results</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Banks P. A., Freeman M. L. Practice parameters committee of the American college of gastroenterology. Practice guidelines in acute pancreatitis, Am. J. Gastroenterol. 101 (10) (2006 Oct) 2379–2400.</mixed-citation><mixed-citation xml:lang="en">Banks P. A., Freeman M. L. Practice parameters committee of the American college of gastroenterology. Practice guidelines in acute pancreatitis, Am. J. Gastroenterol. 101 (10) (2006 Oct) 2379-2400.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Petrov M. S., S. Shanbhag S., Chakraborty M., Phillips A. R., Windsor J. A., Organ failure and infection of pancreatic necrosis as determinants of mortality in patients with acute pancreatitis, Gastroenterology 139 (3) (2010 Sep) 813-820, http://dx.doi.org/10.1053/j.gastro.2010.06.010. Epub 2010 Jun 9. Review.</mixed-citation><mixed-citation xml:lang="en">Petrov M. S., S. Shanbhag S., Chakraborty M., Phillips A. R., Windsor J. A., Organ failure and infection of pancreatic necrosis as determinants of mortality in patients with acute pancreatitis, Gastroenterology 139 (3) (2010 Sep) 813-820, http://dx.doi.org/10.1053/j.gastro.2010.06.010. Epub 2010 Jun 9. Review.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Schmidt P. N., Roug S., Hansen E. F., Knudsen J. D., Novovic S., Spectrum of microorganisms in infected walled-off pancreatic necrosis e impact on organ failure and mortality, Pancreatology 14 (6) (2014 Nov-Dec) 444-449.</mixed-citation><mixed-citation xml:lang="en">Schmidt P. N., Roug S., Hansen E. F., Knudsen J. D., Novovic S., Spectrum of microorganisms in infected walled-off pancreatic necrosis e impact on organ failure and mortality, Pancreatology 14 (6) (2014 Nov-Dec) 444-449.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Shyu J. Y., Sainani N. I., Sahni V. A., Chick J. F., Chauhan N. R., Conwell D. L., Clancy T. E., Banks P. A., Silverman S. G. Necrotizing pancreatitis: diagnosis, imaging, and intervention, Radiographics 34 (5) (2014 Sep-Oct) 1218-1239.</mixed-citation><mixed-citation xml:lang="en">Shyu J. Y., Sainani N. I., Sahni V. A., Chick J. F., Chauhan N. R., Conwell D. L., Clancy T. E., Banks P. A., Silverman S. G. Necrotizing pancreatitis: diagnosis, imaging, and intervention, Radiographics 34 (5) (2014 Sep-Oct) 1218-1239.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Triantopoulou C., Delis S., Dervenis C. Imaging evaluation of post-pancreatitis infection, Infect. Disord. Drug Targets 10 (1) (2010 Feb) 15e20. Review.</mixed-citation><mixed-citation xml:lang="en">Triantopoulou C., Delis S., Dervenis C. Imaging evaluation of post-pancreatitis infection, Infect. Disord. Drug Targets 10 (1) (2010 Feb) 15e20. Review.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma P. K., Madan K., Garg P. K. Hemorrhage in acute pancreatitis: should gastrointestinal bleeding be considered an organ failure? Pancreas 36 (2) (2008 Mar) 141-145.</mixed-citation><mixed-citation xml:lang="en">Sharma P. K., Madan K., Garg P. K. Hemorrhage in acute pancreatitis: should gastrointestinal bleeding be considered an organ failure? Pancreas 36 (2) (2008 Mar) 141-145.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Andersson E., Ansari D., Andersson R. Major haemorrhagic complications of acute pancreatitis, Br. J. Surg. 97 (9) (2010 Sep) 1379-1384.</mixed-citation><mixed-citation xml:lang="en">Andersson E., Ansari D., Andersson R. Major haemorrhagic complications of acute pancreatitis, Br. J. Surg. 97 (9) (2010 Sep) 1379-1384.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Werner J., Feuerbach S., Uhl W., Büchler M. W. Management of acute pancreatitis: from surgery to interventional intensive care. Gut. 2005 Mar;54(3):426-36. doi: 10.1136/gut.2003.035907. PMID: 15710995; PMCID: PMC1774421.</mixed-citation><mixed-citation xml:lang="en">Werner J., Feuerbach S., Uhl W., Büchler M. W. Management of acute pancreatitis: from surgery to interventional intensive care. Gut. 2005 Mar;54(3):426-36. doi: 10.1136/gut.2003.035907. PMID: 15710995; PMCID: PMC1774421.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Wittau M., Scheele J., Gölz I., Henne-Bruns D., Isenmann R. Changing role of surgery in necrotizing pancreatitis: a singlecenter experience. Hepatogastroenterology. 2010 Sep-Oct; 57(102-103):1300-4. PMID: 21410076.</mixed-citation><mixed-citation xml:lang="en">Wittau M., Scheele J., Gölz I, Henne-Bruns D., Isenmann R. Changing role of surgery in necrotizing pancreatitis: a single-center experience. Hepatogastroenterology. 2010 SepOct;57(102-103): 1300-4. PMID: 21410076.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Mier J., León E. L., Castillo A., Robledo F., Blanco R. Early versus late necrosectomy in severe necrotizing pancreatitis. Am J Surg. 1997 Feb;173(2):71-5. doi: 10.1016/S00029610(96)00425-4. PMID: 9074366.</mixed-citation><mixed-citation xml:lang="en">Mier J., León E. L, Castillo A., Robledo F., Blanco R. Early versus late necrosectomy in severe necrotizing pancreatitis. Am J Surg. 1997 Feb;173(2):71-5. doi: 10.1016/S0002-9610(96)00425-4. PMID: 9074366.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Raraty M. G., Halloran C. M., Dodd S., Ghaneh P., Connor S., Evans J., Sutton R., Neoptolemos J. P. Minimal access retroperitoneal pancreatic necrosectomy: improvement in morbidity and mortality with a less invasive approach. Ann Surg. 2010 May;251(5):787-93. doi: 10.1097/SLA.0b013e3181d96c53. PMID: 20395850.</mixed-citation><mixed-citation xml:lang="en">Raraty M. G., Halloran C. M., Dodd S., Ghaneh P., Connor S., Evans J., Sutton R., Neoptolemos J. P. Minimal access retroperitoneal pancreatic necrosectomy: improvement in morbidity and mortality with a less invasive approach. Ann Surg. 2010 May;251(5):787-93. doi: 10.1097/SLA.0b013e3181d96c53. PMID: 20395850.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Bakker O. J., van Santvoort H. C., van Brunschot S., Geskus R. B., Besselink M. G., Bollen T. L., van Eijck C. H., Fockens P., Hazebroek E. J, Nijmeijer R. M., Poley J. W., van Ramshorst B., Vleggaar F. P., Boermeester M. A., Gooszen H. G., Weusten B. L., Timmer R.; Dutch Pancreatitis Study GrouP. Endoscopic transgastric vs surgical necrosectomy for infected necrotizing pancreatitis: a randomized trial. JAMA. 2012 Mar 14;307(10):1053-61. doi: 10.1001/jama.2012.276. PMID: 22416101.</mixed-citation><mixed-citation xml:lang="en">Bakker O. J., van Santvoort H. C., van Brunschot S., Geskus R. B., Besselink M. G., Bollen T. L., van Eijck C. H., Fockens P., Hazebroek E. J., Nijmeijer R. M., Poley J. W., van Ramshorst B., Vleggaar F. P., Boermeester M. A., Gooszen H. G., Weusten B. L., Timmer R.; Dutch Pancreatitis Study GrouP. Endoscopic transgastric vs surgical necrosectomy for infected necrotizing pancreatitis: a randomized trial. JAMA. 2012 Mar 14;307(10):1053-61. doi: 10.1001/jama.2012.276. PMID: 22416101.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Каприн И. А., Эльдорадова Э. Э., Глабай В. П. Хирургическое лечение и осложнения операций при остром панкреатите тяжелого течения. Исследования и практика в медицине. 2018;5(4):72-81.</mixed-citation><mixed-citation xml:lang="en">Kaprin I. A., El‘doradova E. E., Glabaj V. P. Hirurgicheskoe lechenie i oslozhneniya operacij pri ostrom pankreatite tyazhelogo techeniya. Issledovaniya i praktika v medicine. 2018;5(4):72-81.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">L. W. Traverso, R. A. Kozarek, Pancreatic necrosectomy: definitions and technique, J. Gastrointest. Surg. 9 (3) (2005 Mar) 436-439.</mixed-citation><mixed-citation xml:lang="en">L. W. Traverso, R. A. Kozarek, Pancreatic necrosectomy: definitions and technique, J. Gastrointest. Surg. 9 (3) (2005 Mar) 436-439.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">M. G. Raraty, C. M. Halloran, S. Dodd, P. Ghaneh, S. Connor, J. Evans, R. Sutton, J. P. Neoptolemos, Minimal access retroperitoneal pancreatic necrosectomy: improvement in morbidity and mortality with a less invasive approach, Ann. Surg. 251 (5) (2010 May) 787-793.</mixed-citation><mixed-citation xml:lang="en">M. G. Raraty, C. M. Halloran, S. Dodd, P. Ghaneh, S. Connor, J. Evans, R. Sutton, J. P. Neoptolemos, Minimal access retroperitoneal pancreatic necrosectomy: improvement in morbidity and mortality with a less invasive approach, Ann. Surg. 251 (5) (2010 May) 787-793.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">M. L. Freeman, J. Werner, H. C. van Santvoort, T. H. Baron, M. G. Besselink,</mixed-citation><mixed-citation xml:lang="en">M. L. Freeman, J. Werner, H. C. van Santvoort, T. H. Baron, M. G. Besselink,</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">J. A. Windsor, K. D. Horvath, E. vanSonnenberg, T. L. Bollen, S. S. Vege, International multidisciplinary panel of speakers and moderators. Interventions for necrotizing pancreatitis: summary of a multidisciplinary consensus conference, Pancreas 41 (8) (2012 Nov) 1176-1194.</mixed-citation><mixed-citation xml:lang="en">J. A. Windsor, K. D. Horvath, E. vanSonnenberg, T. L. Bollen, S. S. Vege, International multidisciplinary panel of speakers and moderators. Interventions for necrotizing pancreatitis: summary of a multidisciplinary consensus conference, Pancreas 41 (8) (2012 Nov) 1176-1194.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Bugiantella W., Rondelli F., Boni M., Stella P., Polistena A., Sanguinetti A., Avenia N. Necrotizing pancreatitis: A review of the interventions. Int J Surg. 2016 Apr;28 Suppl 1:S163-71. doi: 10.1016/j.ijsu.2015.12.038. Epub 2015 Dec 18. PMID: 26708848.</mixed-citation><mixed-citation xml:lang="en">Bugiantella W., Rondelli F., Boni M., Stella P., Polistena A., Sanguinetti A., Avenia N. Necrotizing pancreatitis: A review of the interventions. Int J Surg. 2016 Apr;28 Suppl 1:S163-71. doi: 10.1016/j.ijsu.2015.12.038. Epub 2015 Dec 18. PMID: 26708848.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">M. G. Besselink, T. J. Verwer, E. J. Schoenmaeckers, E. Buskens, B. U. Ridwan, M. R. Visser, V. B. Nieuwenhuijs, H. G. Gooszen, Timing of surgical intervention in necrotizing pancreatitis, Arch. Surg. 142 (12) (2007 Dec) 1194e1201.</mixed-citation><mixed-citation xml:lang="en">M. G. Besselink, T. J. Verwer, E. J. Schoenmaeckers, E. Buskens, B. U. Ridwan, M. R. Visser, V. B. Nieuwenhuijs, H. G. Gooszen, Timing of surgical intervention in necrotizing pancreatitis, Arch. Surg. 142 (12) (2007 Dec) 1194e1201.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Затевахин И. И. Панкреонекроз: (диагностика, прогнозирование и лечение) : [монография] / Затевахин И. И., Цициашвили М. Ш., Будурова М. Д., Алтунин А. И. – Москва : [б. и.], 2007. – 223 с. : ил., табл.; 22 см.; ISBN 978-5-7809-0064-1</mixed-citation><mixed-citation xml:lang="en">Zatevahin I. I. Pankreonekroz: (diagnostika, prognozirovanie i lechenie) : [monografiya] / Zatevahin I. I., Ciciashvili M. S. H., Budurova M. D., Altunin A. I. – Moskva : [b. i.], 2007. – 223 s. : il., tabl.; 22 sm.; ISBN 978-5-7809-0064-1</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Патент RU № 2320278 С1 МПК А61В 17/00 (2006.01) Российская Федерация Способ формирования илеостомы [текст] / Белоконев В. И., Житлов А. Г. – № 2006122700/14, заявл. 26.06.2006, опубл. 27.07.2008 Бюл. № 9.</mixed-citation><mixed-citation xml:lang="en">Patent RU № 2320278 S1 MPK A61V 17/00 (2006.01) Rossijskaya Federaciya Sposob formirovaniya ileostomy [tekst] / Belokonev V. I., ZHitlov A. G. – № 2006122700/14, zayavl. 26.06.2006, opubl. 27.07.2008 Byul. № 9.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Авижец Ю. Н., Майоров В. М., Дунбаров З. А., Адамович Д. М., Лин В. В., Подольский А. Л. Распространенный ферментативный парапанкреатит как морфологический компанент панкреонекроза по данным аутопсии / Актуальные вопросы хирургии. Материалы XV съезда хирургов Республики Беларусь. – Брест «Альтернатива», 2014: 2016-2017.</mixed-citation><mixed-citation xml:lang="en">Avizhec YU. N., Majorov V. M., Dunbarov Z. A., Adamovich D. M., Lin V. V., Podol‘skij A. L. Rasprostranennyj fermentativnyj parapankreatit kak morfologicheskij kompanent pankreonekroza po dannym autopsii / Aktual’nye voprosy hirurgii. Materialy XV s’ezda hirurgov Respubliki Belarus’. – Brest «Al‘ternativa», 2014: 2016-2017.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Становенко В. В., Подолинский С. Г., Мартов В. Ю., Подолинский Ю. С., Купченко А. М. Лечение деструктивного панкреатита в фазе гнойно-септических осложнений / Актуальные вопросы хирургии. Материалы XV съезда хирургов Республики Беларусь. – Брест «Альтернатива», 2014: 282.</mixed-citation><mixed-citation xml:lang="en">Stanovenko V. V., Podolinskij S. G., Martov V. YU., Podolinskij YU. S., Kupchenko A. M. Lechenie destruktivnogo pankreatita v faze gnojno-septicheskih oslozhnenij / Aktual‘nye voprosy hirurgii. Materialy XV s»ezda hirurgov Respubliki Belarus‘. – Brest «Al‘ternativa», 2014: 282.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Григорьев Е. Г., Садах М. В., Бойко Т. Н., Капорский В. И., Гельфанд С. А., Дворянов Я. А., Калиниченко А. В., Колмаков С. А. Некротический мезои параколит в терминальной стадии инфицированного панкреонекроза. Инфекции в хирургии. 2008; (4):38-42.</mixed-citation><mixed-citation xml:lang="en">Grigor’ev E. G., Sadah M. V., Bojko T. N., Kaporskij V. I., Gel‘fand S. A., Dvoryanov YA. A., Kalinichenko A. V., Kolmakov S. A. Nekroticheskij mezoi parakolit v terminal‘noj stadii inficirovannogo pankreonekroza. Infekcii v hirurgii. 2008;(4):38-42.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
