milmedВоенная медицинаMilitary Medicine2074-5044Белорусский государственный медицинский университет10.51922/2074-5044.2024.2.44milmed-216Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESГенетические биомаркеры ответа на болезнь-модифицирующую терапию рассеянного склерозаGenetic Biomarkers of Response to Disease-Modifying Therapy for Multiple Sclerosis (Literature Review)МосковскихЮ. В.MoskovskikhY. V.ФедуловА. С.FedulovA. S.БорисовА. В.BarysauA. V.МорозикП. М.MarozikP. M.ВолковаН. А.VolkavaN. A.СупрунВ. Е.SuprunV. E.ГатальскаяМ. Д.GatalskayaM. D.УО «Белорусский государственный медицинский университет»BelarusГНУ «Институт Генетики и Цитологии НАН Беларуси»Russian FederationГУ «Минский научно-практический центр хирургии, трансплантологии и гематологии»Belarus202425082026024455Copyright © Московских Ю.В., Федулов А.С., Борисов А.В., Морозик П.М., Волкова Н.А., Супрун В.Е., Гатальская М.Д., 20262026Московских Ю.В., Федулов А.С., Борисов А.В., Морозик П.М., Волкова Н.А., Супрун В.Е., Гатальская М.Д.Moskovskikh Y.V., Fedulov A.S., Barysau A.V., Marozik P.M., Volkava N.A., Suprun V.E., Gatalskaya M.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://milmed.ejournal.by/jour/article/view/216

В представленном обзоре рассматриваются фармакогенетические маркеры ответа пациентов с рассеянным склерозом (РС) на болезнь-модифицирующую терапию (БМТ). Оценка результатов уже проведенных фармакогенетических исследований указывает на то, что при таком заболевании, как РС, для того, чтобы эффективно выявлять пациентов-респондеров на БМТ, имеющих при этом низкий риск развития нежелательных явлений, необходимо оценивать множественные генетические биомаркеры. Исследования по выявлению соответствующих биомаркеров находятся в стадии реализации, и их результаты необходимо будет распространить на все технологии БМТ. Однако прежде, чем они могут быть использованы в клинической практике, необходима проверка на больших группах пациентов.

This review examines pharmacogenetic markers of the response of patients with multiple sclerosis (MS) to disease-modifying therapy (DMT). Evaluation of the results of pharmacogenetic studies already conducted indicates that in such a complex disease as MS, in order to effectively identify patients who are responders to BMT and have a low risk of developing adverse events, it will be necessary to simultaneously evaluate multiple genetic biomarkers. Research to identify relevant biomarkers is underway and the results will need to be extended to all BMT technologies. It should be understood, however, that extensive testing in large groups of patients will be required before they can be used in clinical practice.

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The authors declare that there are no conflicts of interest present.