<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">milmed</journal-id><journal-title-group><journal-title xml:lang="ru">Военная медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Military Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-5044</issn><publisher><publisher-name>Белорусский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51922/2074-5044.2023.4.43</article-id><article-id custom-type="elpub" pub-id-type="custom">milmed-283</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ НАУЧНЫЕ ПУБЛИКАЦИИ. Лечебно-профилактические вопросы</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL SCIENTIFIC PUBLICATIONS. Medical and preventive questions</subject></subj-group></article-categories><title-group><article-title>Вариабельность сердечного ритма и гипофизарно-надпочечниковая функция у пациентов с псориазом</article-title><trans-title-group xml:lang="en"><trans-title>HEART RATE VARIABILITY AND PITUITARY-ADRENAL FUNCTION IN PATIENTS WITH PSORIASIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сикорская</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sikorskaya</surname><given-names>T. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Музыченко</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Muzychenko</surname><given-names>A. P.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Качук</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kachuk</surname><given-names>M. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сикорский</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sikorski</surname><given-names>А. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Микульчик</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mikulchik</surname><given-names>N. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>УО «Белорусский государственный медицинский университет»</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>28</day><month>08</month><year>2026</year></pub-date><volume>0</volume><issue>4</issue><fpage>43</fpage><lpage>54</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сикорская Т.А., Музыченко А.П., Качук М.В., Сикорский А.В., Микульчик Н.В., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Сикорская Т.А., Музыченко А.П., Качук М.В., Сикорский А.В., Микульчик Н.В.</copyright-holder><copyright-holder xml:lang="en">Sikorskaya T.A., Muzychenko A.P., Kachuk M.V., Sikorski А.V., Mikulchik N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://milmed.ejournal.by/jour/article/view/283">https://milmed.ejournal.by/jour/article/view/283</self-uri><abstract><p>Проведено исследование вариабельности сердечного ритма и функции оси гипофиз-надпочечники у 91 пациента с различными формами псориаза.</p><p>Установлены напряжение регуляторных систем сердечного ритма и расстройства вегетативной нервной системы, которые выявляются в условиях активной ортостатической пробы.</p><p>Нарушение автономной нервной системы сочеталось с высокой глюкокортикоидной и минералокортикоидной активностью надпочечников.</p><p>Выявлена разница в показателях ритма сердца, гормонов гипофиза и надпочечников у пациентов со стрептококк-ассоциированном псориазе и псориазе без стрептококковой ассоциации.</p></abstract><trans-abstract xml:lang="en"><p>The study of heart rate variability and the function of the pituitary-adrenal axis was carried out in 91 patients with various forms of psoriasis.</p><p>The tension of the regulatory systems of the heart rhythm and disorders of the autonomic nervous system observed in conditions of an active orthostatic test were established.</p><p>Impairment of the autonomic nervous system was associated with high glucocorticoid and mineralocorticoid activity of the adrenal glands.</p><p>The difference in the heart rate, pituitary and adrenal hormones was revealed in patients with streptococcus-associated psoriasis and psoriasis without streptococcal association.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>псориаз</kwd><kwd>стрептококк-ассоциированный псориаз</kwd><kwd>вариабельность сер- дечного ритма</kwd><kwd>вегетативная нервная система</kwd><kwd>надпочечники</kwd><kwd>активная клиноортостатическая проба</kwd></kwd-group><kwd-group xml:lang="en"><kwd>psoriasis</kwd><kwd>streptococcus-associated psoriasis</kwd><kwd>heart rate variability</kwd><kwd>autonomic nervous system</kwd><kwd>adrenal glands</kwd><kwd>active orthostatic test</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Влияние на иммунопатогенез псориаза дефицита эндокринно-метаболических факторов / О.В. Самбурская [и др.] // Аллергология и иммунология. – 2022. – № 1 (23). – С. 12–14.</mixed-citation><mixed-citation xml:lang="en">Vliyanie na immunopatogenez psoriaza deficita endokrinno-metabolicheskih faktorov [The effect ofvitamin d on the biochemical pathways of the development of metabolic disorders in psoriasis (review article)] / O.V. Samburskaya [i dr.] // Allergologiya i immunologiya. – 2022. – № 1 (23). – S. 12–14.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Кубанов, А.А. Эпидемиология псориаза в Российской Федерации (по данным регистра) / А.А. Кубанов, Е.В. Богданова // Вестник дерматологии и венерологии. – 2022. – № 2 (98). – С. 33–41.</mixed-citation><mixed-citation xml:lang="en">Kubanov, A.A. Epidemiologiya psoriaza v Rossijskoj Federacii (po dannym registra) [Epidemiology of psoriasis in the Russian Federation (according to the register)] / A.A. Kubanov, E.V. Bogdanova // Vestnik dermatologii i venerologii. – 2022. – № 2 (98). – S. 33–41.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Машина, М.В. Особенности патогенеза автономной и периферической невропатии у больных псориазом / М.В. Машина, А.С. Нестеров, Л.А. Белова // Ульяновский медико-биологический журнал. – 2023. – № 1. – С. 63–73.</mixed-citation><mixed-citation xml:lang="en">Mashina, M.V. Osobennosti patogeneza avtonomnoj i perifericheskoj nevropatii u bolnyh psoriazom [Features of the pathogenesis of autonomic and peripheral neuropathy in patients with psoriasis] / M.V. Mashina, A.S. Nesterov, L.A. Belova // Ulyanovskij mediko-biologicheskij zhurnal. – 2023. – № 1. – S. 63–73.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Методы исследования сердечного ритма по данным ЭКГ: вариабельность сердечного ритма и дисперсионное картирование (Обзорная статья) / Е.М. Новиков [и др.] // Кремлевская медицина. Клинический вестник. – 2019. – № 4. – С. 81–89.</mixed-citation><mixed-citation xml:lang="en">Metody issledovaniya serdechnogo ritma po dannym EKG: variabelnost serdechnogo ritma i dispersionnoe kartirovanie (Obzornaya statya) [Methods for studying heart rate according to ECG data: heart rate variability and dispersion mapping (Review article)] / E.M. Novikov [i dr.] // Kremlevskaya medicina. Klinicheskij vestnik. – 2019. – № 4. – S. 81–89.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Патрушев, А.В. Очаговая инфекция и течение хронических дерматозов: современный взгляд на проблему / А.В. Патрушев, А.В. Самцов, А.В. Сухарев // Военно-медицинский журнал. – 2021. – № 2. – С. 45–52.</mixed-citation><mixed-citation xml:lang="en">Patrushev, A.V. Ochagovaya infekciya i techenie hronicheskih dermatozov: sovremennyj vzglyad na problem [Focal infection and the course of chronic dermatoses: a modern view of the problem] / A.V. Patrushev, A.V. Samcov, A.V. Suharev // Voenno-medicinskij zhurnal. – 2021. – № 2. – S. 45–52.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Психодинамические аспекты в исследовании структуры личности пациентов с псориатической болезнью / Сятковский, В.А. [и др.] // Дерматология. Косметология. – 2023. – № 1 (9). – С. 29–39.</mixed-citation><mixed-citation xml:lang="en">Psihodinamicheskie aspekty v issledovanii struktury lichnosti pacientov s psoriaticheskoj boleznyu [Psychodynamic aspects in the study of the personality structure of patients with psoriatic disease] / Syatkovskij, V.A. [i dr.] // Dermatologiya. Kosmetologiya. – 2023. – № 1 (9). – S. 29–39.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Сикорская, Т.А. Состояние протеиназно-ингибиторной системы и уровень эндогенной интоксикации у пациентов с вульгарным псориазом / Т.А. Сикорская // Медицина. – 2015. – № 1 (88). – С. 19–26.</mixed-citation><mixed-citation xml:lang="en">Sikorskaya, T.A. Sostoyanie proteinazno-ingibitornoj sistemy i uroven‘ endogennoj intoksikacii u pacientov s vulgarnym psoriazom [The state of the proteinase-inhibitory system and the level of endogenous intoxication in patients with psoriasis vulgaris] / T.A. Sikorskaya // Medicina. – 2015. – № 1 (88). – S. 19–26.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Содержание адренокортикотропного гормона в экссудатах кожного окна при некоторых иммуноопосредовых заболеваниях кожи / Д.С. Загрешенко [и др.] // Медицина в Кузбассе. – 2022. – № 4. – С. 49–52.</mixed-citation><mixed-citation xml:lang="en">Soderzhanie adrenokortikotropnogo gormona v ekssudatah kozhnogo okna pri nekotoryh immunooposredovyh zabolevaniyah kozhi [The content of adrenocorticotropic hormone in exudates of the skin window in some immune-mediated skin diseases] / D.S. Zagreshenko [i dr.] // Medicina v Kuzbasse. – 2022. – № 4. – S. 49–52.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Сорокина, Е.В. Роль клеток врожденной иммунной системы при псориазе / Е.В. Сорокина, И.В. Бишева // Вестник дерматологии и венерологии. – 2022. – № 5 (98). – С. 59–64.</mixed-citation><mixed-citation xml:lang="en">Sorokina, E.V. Rol kletok vrozhdennoj immunnoj sistemy pri psoriaze [The role of cells of the innate immune system in psoriasis] / E.V. Sorokina, I.V Bisheva // Vestnik dermatologii i venerologii. – 2022. – № 5 (98). – S. 59–64.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Фролов, А.В. Новый взгляд на нормализацию параметров сердечно-сосудистой системы // Медицинская панорама. – 2003. – № 8. – С. 50–52.</mixed-citation><mixed-citation xml:lang="en">Frolov, A.V. Novyj vzglyad na normalizaciyu parametrov serdechno-sosudistoj sistemy [A new look at the normalization of parameters of the cardiovascular system] // Medicinskaya panorama. – 2003. – № 8. – S. 50–52.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Хлебникова, А.Н. Роль эпидермальных липидов в патогенезе псориаза / А. Н. Хлебникова // Клиническая дерматология и венерология. – 2020. – № 2 (19). – С. 231–234.</mixed-citation><mixed-citation xml:lang="en">Hlebnikova, A.N. Rol epidermalnyh lipidov v patogeneze psoriaza / A. N. Hlebnikova [The role of epidermal lipids in the pathogenesis of psoriasis] // Klinicheskaya dermatologiya i venerologiya. – 2020. – № 2 (19). – S. 231–234.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Brynina, A.V. Comorbid conditions in psoriasis / A.V. Brynina, D.R. Gimhan, A I. Wickramage // Journal of the Grodno State Medical University. – 2023. – № 1 (21). – Р. 12–18.</mixed-citation><mixed-citation xml:lang="en">Brynina, A.V. Comorbid conditions in psoriasis / A.V. Brynina, D.R. Gimhan, A I. Wickramage // Journal of the Grodno State Medical University. – 2023. – № 1 (21). – Р. 12–18.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">New aspects of the pathogenesis of psoriasis / A.S. Zhukov [et al.] // Vestnik Dermatologii i Venerologii. – 2022. – № 4 (98). – Р. 31–40.</mixed-citation><mixed-citation xml:lang="en">New aspects of the pathogenesis of psoriasis / A.S. Zhukov [et al.] // Vestnik Dermatologii i Venerologii. – 2022. – № 4 (98). – Р. 31–40.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Psoriasis, chronic tonsillitis, and biofilms: Tonsillar pathologic findings supporting a microbial hypothesis / Н. Allen [et al.] // Ear Nose Throat J. – 2020. – № 3 (97). – Р. 79–82.</mixed-citation><mixed-citation xml:lang="en">Psoriasis, chronic tonsillitis, and biofilms: Tonsillar pathologic findings supporting a microbial hypothesis / Н. Allen [et al.] // Ear Nose Throat J. – 2020. – № 3 (97). – Р. 79–82.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Study on the Impact of Psoriasis on Quality of Life: Psychological, Social and Financial Implications / V. Bulat [et al.] // Psychiatr Danub. – 2020. – № 4 (32). – Р. 553–561.</mixed-citation><mixed-citation xml:lang="en">Study on the Impact of Psoriasis on Quality of Life: Psychological, Social and Financial Implications / V. Bulat [et al.] // Psychiatr Danub. – 2020. – № 4 (32). – Р. 553–561.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
