milmedВоенная медицинаMilitary Medicine2074-5044Белорусский государственный медицинский университет10.51922/2074-5044.2023.3.47milmed-339Research ArticleОРИГИНАЛЬНЫЕ НАУЧНЫЕ ПУБЛИКАЦИИ. Лечебно-профилактические вопросыORIGINAL SCIENTIFIC PUBLICATIONS. Medical and preventive questionsГенетические маркеры фармакокинетических особенностей у пациентов с тяжелым исходом шизофрении, резистентных к терапии антипсихотикамиPharmacokinetic marker genes of patients with severe schizophrenia resistant to antipsychotic therapyОбъедковВ. Г.ObyedkovV. G.ГолоенкоИ. М.HalayenkaI. M.БокутьО. С.BokutO. S.ДокукинаТ. В.DokukinaT. V.ГолубеваТ. С.GolubevaT. S.ТишкевичЛ. А.TishkevichL. A.ХоджаевА. В.KhodzhaevA. V.УО «Белорусский государственный медицинский университет»BelarusГНУ «Институт генетики и цитологии НАН Беларуси»BelarusГНУ «Институт биоорганической химии НАН Беларуси»BelarusГУ РНПЦ психического здоровья МЗ РБBelarus202329082026034752Copyright © Объедков В.Г., Голоенко И.М., Бокуть О.С., Докукина Т.В., Голубева Т.С., Тишкевич Л.А., Ходжаев А.В., 20262026Объедков В.Г., Голоенко И.М., Бокуть О.С., Докукина Т.В., Голубева Т.С., Тишкевич Л.А., Ходжаев А.В.Obyedkov V.G., Halayenka I.M., Bokut O.S., Dokukina T.V., Golubeva T.S., Tishkevich L.A., Khodzhaev A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://milmed.ejournal.by/jour/article/view/339

Ответ на лекарственную терапию обусловлен генетическими особенностями фармакокинетических и фармакодинамических процессов в организме человека. Изучение связи генетических факторов и резистентности пациентов с тяжелым исходом необходимо для понимания причин формирования данного эндофенотипа шизофрении. Проведенный нами анализ показал более частое сочетание тяжелого исхода шизофрении с аллелями генов, контролирующих периферический метаболизм ксенобиотиков и обуславливающих фармакокинетические процессы антипсихотической терапии.

The response to drug therapy is determined by the genetic characteristics of pharmacokinetic and pharmacodynamic processes in the human body. The study of the relationship between genetic factors and the resistance of patients with severe outcome is necessary to understand the causes of the formation of this endophenotype of schizophrenia. Our analysis showed a more frequent combination of a severe outcome of schizophrenia with alleles of genes that control the peripheral metabolism of xenobiotics and cause the pharmacokinetic processes of antipsychotic therapy.

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The authors declare that there are no conflicts of interest present.