milmedВоенная медицинаMilitary Medicine2074-5044Белорусский государственный медицинский университет10.51922/2074-5044.2026.3.86milmed-362Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESФармакогеномика метотрексата и генов-кандидатов у пациентов с идиопатическим артритомPharmacogenomics of methotrexate and candidate genes in patients with idiopathic arthritisНазарчукИ. И.NazarchukI. I.

Минск

Minsk

СтрогийВ. В.StrogijV. V.

Минск

Minsk

ВолковаО. Н.VolkovaO. N.

Минск

Minsk

УО «Белорусский государственный медицинский университет»БеларусьBelarusian State Medical UniversityBelarus202601092026038697Copyright © Назарчук И.И., Строгий В.В., Волкова О.Н., 20262026Назарчук И.И., Строгий В.В., Волкова О.Н.Nazarchuk I.I., Strogij V.V., Volkova O.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://milmed.ejournal.by/jour/article/view/362

Статья представляет собой обстоятельный обзор генетических факторов, влияющих на фармакокинетику и эффект метотрексата (МТХ) при лечении ювенильного идиопатического артрита (ЮИА). В ней подробно рассмотрены ключевые гены и их полиморфизмы, связанные с метаболизмом и транспортом МТХ, а также влияние на эффективность и переносимость терапии МТХ. Целью исследования является проведение обзора результатов генетических исследований, направленных на поиск маркеров, которые могут влиять на индивидуальные различия в фармакокинетике МТХ; дать характеристику наиболее хорошо изученным генам, участвующим в фармакогеномике МТХ и генам-кандидатам у пациентов с ЮИА, В статье проведен анализ результатов генетических исследований, опубликованных ведущими международными профессиональными сообществами специалистов в данной сфере. Проведен поиск информации в сети PubMed, eLIBRARY. RU, Google Scholar, ClinPGx, по ключевым словам.

This article provides a comprehensive review of genetic factors that influence the pharmacokinetics and effects of methotrexate (MTX) in the treatment of juvenile idiopathic arthritis (JIA). It focuses on key genes and polymorphisms associated with MTX metabolism and transport, as well as their impact on the efficacy and tolerability of MTX therapy. The aim of the study is to review the results of genetic studies aimed at finding markers that can influence individual differences in the pharmacokinetics of MTX; to characterize the most well-studied genes involved in the pharmacogenomics of MTX and candidate genes in patients with JIA. The article analyzes the results of genetic studies published by leading international professional communities of specialists in this field. Information was searched in the PubMed and eLibrary networks.RU, Google Scholar, ClinPGx, by keywords.

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The authors declare that there are no conflicts of interest present.