milmedВоенная медицинаMilitary Medicine2074-5044Белорусский государственный медицинский университет10.51922/2074-5044.2026.1.90milmed-44Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESВлияние липополисахарида и активных форм кислорода на механизм активации тромбоцитов и сосудистые реакцииInfluence of the type and style of fever, smoking status, degree of androgenetic alopecia on the phases of hair growth in military servicemen under inpatient treatment with a diagnosis of pneumoniaКременецкийЕ. И.KremenetskyE. I.ХодосовскийМ. Н.KhodosovskyM. N.ГУ «432 ордена Красной Звезды главный военный клинический медицинский центр Вооруженных Сил Республики Беларусь»БеларусьState Institution «432 Orders of the Red Star Main Military Clinical Medical Center of the Armed Forces of the Republic of Belarus»BelarusУО «Гродненский государственный медицинский университет»БеларусьEducational institution «Grodno State Medical University»Belarus202621082026019093Copyright © Кременецкий Е.И., Ходосовский М.Н., 20262026Кременецкий Е.И., Ходосовский М.Н.Kremenetsky E.I., Khodosovsky M.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://milmed.ejournal.by/jour/article/view/44

В статье рассматривается роль липополисахарида (ЛПС) грамотрицательных бактерий, в активации тромбоцитов и сосудистых реакциях. ЛПС взаимодействует с рецептором TLR4 на тромбоцитах, усиливая их агрегацию и продукцию активных форм кислорода (АФК), что способствует высвобождению факторов, участвующих в воспалении и коагуляции. Механизм действия включает фосфорилирование ключевых сигнальных белков (Akt, ERK1/2, PLA2) через путь TLR4-PI3K-Akt-ERK1/2, зависимый от АФК и тромбоксана A₂. Влияние ЛПС проявляется также в снижении сосудистой релаксации и увеличении проницаемости сосудов, а реакции на его концентрацию варьируют от усиления продукции АФК до повышения уровней воспалительных медиаторов. АФК играют важную роль в передаче сигналов, активируя каскады MAPK и NF-κB, что способствует экспрессии ферментов и цитокинов, регулирующих воспаление и сосудистую функцию. АФК играет важную роль как посредник в механизмах воспаления и активации тромбоцитов под действием ЛПС, а также их влияние на синтез простаноидов и сосудистые реакции.Большинство НПВП активны против PGHS-1. В цельной крови, стимулированной ЛПС, S-ибупрофен заметно снижает уровни TXB(2) в диапазоне концентраций от 10 до 200 мкг/мл и агрегацию тромбоцитов при лихорадочных состояниях.

The article discusses the role of lipopolysaccharide (LPS) of gram-negative bacteria in platelet activation and vascular reactions. LPS interacts with the TLR4 receptor on platelets, enhancing their aggregation and production of reactive oxygen species (ROS), which promotes the release of factors involved in inflammation and coagulation. The mechanism of action involves phosphorylation of key signaling proteins (Akt, ERK1/2, PLA2) through the TLR4-PI3K-Akt-ERK1/2 pathway, dependent on ROS and thromboxane A₂. The effect of LPS is also manifested in a decrease in vascular relaxation and an increase in vascular permeability, and reactions to its concentration range from increased ROS production to increased levels of inflammatory mediators. ROS play an important role in signaling by activating the MAPK and NF-kB cascades, which promotes the expression of enzymes and cytokines that regulate inflammation and vascular function. ROS plays an important role as an intermediary in the mechanisms of inflammation and platelet activation under the action of LPS, as well as their effect on prostanoid synthesis and vascular reactions.Most NSAIDs are active against PGHS-1 In LPS-stimulated whole blood, S-ibuprofen markedly reduces TXB(2) levels in the concentration range of 10 to 200 μg/ml and platelet aggregation in non-inflammatory and inflammatory fever.

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The authors declare that there are no conflicts of interest present.