milmedВоенная медицинаMilitary Medicine2074-5044Белорусский государственный медицинский университетmilmed-512Research ArticleОРИГИНАЛЬНЫЕ НАУЧНЫЕ ПУБЛИКАЦИИ. Лечебно-профилактические вопросыORIGINAL SCIENTIFIC PUBLICATIONS. Medical and preventive questionsВзаимосвязь клинических симптомов шизофрении с острыми лекарственно индуцированными экстрапирамидными расстройствамиThe relationship between clinical symptoms of schizophrenia and acute drug-induced extrapyramidal disordersГоргунО. В.GorgunO. V.УО «Белорусский государственный медицинский университет»Belarus201820102026011420Copyright © Горгун О.В., 20262026Горгун О.В.Gorgun O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://milmed.ejournal.by/jour/article/view/512

Исследования посвящены клинико-биологической феноменологии острых лекарственно индуцированных экстрапирамидных расстройств при шизофрении. В статье приводятся результаты исследований связи клинической симптоматики шизофрении с острыми паркинсонизмом и акатизией, возникшими в результате назначения пациентам стандартизированной антипсихотической терапии. Было обнаружено, что лекарственно индуцированная акатизия достоверно чаще связана с такими общими психопатологическими симптомами, как тревога, депрессия, аффективная лабильность, ослабление контроля импульсивности и активная социальная устраненность. Лекарственно индуцированный паркинсонизм обнаружил связь с негативной симптоматикой, а также с моторной заторможенностью и волевыми нарушениями.

Studies are devoted to the clinical and biological phenomenology of acute drug-induced extrapyramidal disorders in schizophrenia. The article presents the results of studies of the association of clinical symptoms of schizophrenia with acute parkinsonism and akathisia, which resulted from the administration of standardized antipsychotic therapy to patients. It has been found that drug-induced akathisia is more reliably associated with such common psychopathological symptoms as anxiety, depression, affective lability, impaired control impairment, and active social exclusion. Drug-induced Parkinsonism revealed a relationship with negative symptoms, as well as motor retardation and violent impairment.

шизофрениялекарственно индуцированная акатизиянейролептический паркинсонизмschizophreniadrug induced akathisianeuroleptic parkinsonismReferencesJablensky A. (2000) Epidemiology of schizophrenia: the global burden of disease and disability. Eur Arch Psychiatry ClinNeurosci. Vol. 250, no. 6, pp. 274–285.Jablensky A. (2000) Epidemiology of schizophrenia: the global burden of disease and disability. Eur Arch Psychiatry ClinNeurosci. Vol. 250, no. 6, pp. 274–285.Gerlach J, Peacock L.(1995) New antipsychotics: the present status. In ClinPsychopharmacol. Vol. 10, pp. 39–48.Gerlach J, Peacock L.(1995) New antipsychotics: the present status. In ClinPsychopharmacol. Vol. 10, pp. 39–48.Steck H. (2006) Extrapyramidal and diencephalic syndrome in the course of largactil and serpasil treatments. Ann Med Psychol (Paris). Vol.12, pp.737–744.Steck H. (2006) Extrapyramidal and diencephalic syndrome in the course of largactil and serpasil treatments. Ann Med Psychol (Paris). Vol.12, pp.737–744.Poyurovsky M (2010). Acute antipsychotic-induced akathisia revisited. Br J Psychiatry. Vol. 196, no. 2, pp. 89–91.Poyurovsky M (2010). Acute antipsychotic-induced akathisia revisited. Br J Psychiatry. Vol. 196, no. 2, pp. 89–91.Плотникова Е. В. (2009) Лекарственно-индуцированные двигательные расстройства при шизофрении. Таврический медико-биологический вестник. Т. 12, № 1 (45). С. 192–199.Плотникова Е. В. (2009) Лекарственно-индуцированные двигательные расстройства при шизофрении. Таврический медико-биологический вестник. Т. 12, № 1 (45). С. 192–199.Sachdev P (2004) Early extrapyramidal side-effects as risk factors for later tardive dyskinesia: a prospective study. Aust N Z J Psychiatry. Vol. 38, no.6, pp. 445–9.Sachdev P (2004) Early extrapyramidal side-effects as risk factors for later tardive dyskinesia: a prospective study. Aust N Z J Psychiatry. Vol. 38, no.6, pp. 445–9.Duncan E. J., Adler L. A., Stephanides M. et al. (2000) Akathisia and exacerbation of psychopathology: a preliminary report. ClinNeuropharmacol. Vol. 23, pp. 169–173.Duncan E. J., Adler L. A., Stephanides M. et al. (2000) Akathisia and exacerbation of psychopathology: a preliminary report. ClinNeuropharmacol. Vol. 23, pp. 169–173.PeitlM. V., ProloščićJ., Blažević-ZelićS. (2011) Et al. Symptoms of agitated depression and/or akathisia. Psychiatr Danub. Vol. 23, no. 1, pp. 108–110.PeitlM. V., ProloščićJ., Blažević-ZelićS. (2011) Et al. Symptoms of agitated depression and/or akathisia. Psychiatr Danub. Vol. 23, no. 1, pp. 108–110.Reid A. M., McNamara J. P, Murphy T. K. (2015) Side-effects of SSRIs disrupt multimodal treatment for pediatric OCD in a randomized-controlled trial. J Psychiatr Res. Vol. 71, pp. 140–147.Reid A. M., McNamara J. P, Murphy T. K. (2015) Side-effects of SSRIs disrupt multimodal treatment for pediatric OCD in a randomized-controlled trial. J Psychiatr Res. Vol. 71, pp. 140–147.Lipinski J. F. Jr., Mallya G., Zimmerman P. et al.(1989) Fluoxetine-induced akathisia: clinical and theoretical implications. J Clin Psychiatry. Vol. 50, no. 9, pp. 339–342.Lipinski J. F. Jr., Mallya G., Zimmerman P. et al.(1989) Fluoxetine-induced akathisia: clinical and theoretical implications. J Clin Psychiatry. Vol. 50, no. 9, pp. 339–342.Temmingh H., Stein D. J. (2015) Anxiety in Patients with Schizophrenia: Epidemiology and Management. CNS Drugs. Vol. 29, no.10, pp. 819–832.Temmingh H., Stein D. J. (2015) Anxiety in Patients with Schizophrenia: Epidemiology and Management. CNS Drugs. Vol. 29, no.10, pp. 819–832.Kim JH, Byun HJ (2009). Non-motor cognitive-perceptual dysfunction associated with drug-induced parkinso-nism. Hum Psychopharmacol. Vol. 24, no. 2, pp. 129–134.Kim JH, Byun HJ (2009). Non-motor cognitive-perceptual dysfunction associated with drug-induced parkinso-nism. Hum Psychopharmacol. Vol. 24, no. 2, pp. 129–134.Kim JH, Kim SY, Byun HJ (2008). Subjective cognitive dysfunction associated with drug-induced parkinsonism in schizophrenia. Parkinsonism Relat. Disord. Vol. 14, no. 3, pp. 239–242.Kim JH, Kim SY, Byun HJ (2008). Subjective cognitive dysfunction associated with drug-induced parkinsonism in schizophrenia. Parkinsonism Relat. Disord. Vol. 14, no. 3, pp. 239–242.Федорова Н. В., Ветохина Т. Н. (2009) Диагностика и лечение нейролептических экстрапирамидных синдромов. Псих. расстройства в общей медицине. – № 3.Федорова Н. В., Ветохина Т. Н. (2009) Диагностика и лечение нейролептических экстрапирамидных синдромов. Псих. расстройства в общей медицине. – № 3.Беккер Р. А., Быков Ю. В. Акатизия: клинический анализ патологии с рекомендациями и обзором литературы. Consilium Medicum: Публикации партнеров.Беккер Р. А., Быков Ю. В. Акатизия: клинический анализ патологии с рекомендациями и обзором литературы. Consilium Medicum: Публикации партнеров.Berrios G. E. (1995) Lad Haskovec and akathisia: an introduction. Hist Psychiatry. Vol. 6, pp. 243–251Berrios G. E. (1995) Lad Haskovec and akathisia: an introduction. Hist Psychiatry. Vol. 6, pp. 243–251Mohr P., Volavka J. (2002) LadislavHaskovec and akathisia: 100th anniversary. Br J Psychiatry. Vol. 12, pp. 181–237.Mohr P., Volavka J. (2002) LadislavHaskovec and akathisia: 100th anniversary. Br J Psychiatry. Vol. 12, pp. 181–237.Sachdev P. (1995) The development of the concept of akathisia: a historical overview. Schizophr Res. Vol. 16, no. 1, pp. 33–45.Sachdev P. (1995) The development of the concept of akathisia: a historical overview. Schizophr Res. Vol. 16, no. 1, pp. 33–45.Sachdev P (1995). The epidemiology of drug-induced akathisia: Part I. Acute akathisia. SchizophrBull. Vol. 21, no. 3, pp. 431–449. Availabe:http://psycnet.apa.org/psycinfo/1996–09010–001.Sachdev P (1995). The epidemiology of drug-induced akathisia: Part I. Acute akathisia. SchizophrBull. Vol. 21, no. 3, pp. 431–449. Availabe:http://psycnet.apa.org/psycinfo/1996–09010–001.Sachdev P. (1995) The classification of akathisia. MovDisord. Vol. 10, no. 2, pp. 235–237.Sachdev P. (1995) The classification of akathisia. MovDisord. Vol. 10, no. 2, pp. 235–237.Duncan E. J., Adler L. A., Stephanides M. et al. (2000) Akathisia and exacerbation of psychopathology: a preliminary report. ClinNeuropharmacol. Vol. 23, pp. 169–173.Duncan E. J., Adler L. A., Stephanides M. et al. (2000) Akathisia and exacerbation of psychopathology: a preliminary report. ClinNeuropharmacol. Vol. 23, pp. 169–173.PeitlM. V., Prološčić J., Blažević-Zelić S. etal. Symptoms of agitated depression and/or akathisia. PsychiatrDanub. Vol. 23, no. 1, pp. 108–110.PeitlM. V., Prološčić J., Blažević-Zelić S. etal. Symptoms of agitated depression and/or akathisia. PsychiatrDanub. Vol. 23, no. 1, pp. 108–110.Левин О. С., Шиндряева Н. Н., Аникина М. А. (2012) Лекарственный паркинсонизм. Журнал неврологии и психиатрии им. С. С. Корсакова. № 8. – С. 69–74.Левин О. С., Шиндряева Н. Н., Аникина М. А. (2012) Лекарственный паркинсонизм. Журнал неврологии и психиатрии им. С. С. Корсакова. № 8. – С. 69–74.Nair C. J., Josiassen R. C., Abraham G. et al. Does akathisia influence psychopathology inpsychotic patients treated with clozapine? Biol Psychiatry. 1999; 45(10):1376–1383.Nair C. J., Josiassen R. C., Abraham G. et al. Does akathisia influence psychopathology inpsychotic patients treated with clozapine? Biol Psychiatry. 1999; 45(10):1376–1383.Peitl M. V., ProloščićJ., Blažević-ZelićS. Et al. (2010) Symptoms of agitated depression and/or akathisia. PsychiatrDanub. Vol. 23, no. 1, pp. 108–110.Peitl M. V., ProloščićJ., Blažević-ZelićS. Et al. (2010) Symptoms of agitated depression and/or akathisia. PsychiatrDanub. Vol. 23, no. 1, pp. 108–110.Hardie RJ, Lees AJ (1988). Neuroleptic-induced Parkinson's syndrome: clinical features and results of treatment with levodopa. J. Neurol. Neurosurg. Psychiatr. Vol. 51, no. 6, pp. 850–854.Hardie RJ, Lees AJ (1988). Neuroleptic-induced Parkinson's syndrome: clinical features and results of treatment with levodopa. J. Neurol. Neurosurg. Psychiatr. Vol. 51, no. 6, pp. 850–854.Chouinard G, Ross-Chouinard A, Annable L, et al.: Extrapyramidal Rating Scale. The Canadian Journal of Neurological Sciences 7:233–239, 1980.Chouinard G, Ross-Chouinard A, Annable L, et al.: Extrapyramidal Rating Scale. The Canadian Journal of Neurological Sciences 7:233–239, 1980.Kay SR, Fiszbein A, Opler LA (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 13 (2): 261–76. PMID 3616518. doi:10.1093/schbul/13.2.261.Kay SR, Fiszbein A, Opler LA (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 13 (2): 261–76. PMID 3616518. doi:10.1093/schbul/13.2.261.Lindenmayer, J. P. Five factor model of schizophrenia: Replication across samples / J. P. Lindenmayer, S. Grochowski, R. B. Hyman // Schizophr. Res. – 1995. – Vol. 14. – P. 229–234.Lindenmayer, J. P. Five factor model of schizophrenia: Replication across samples / J. P. Lindenmayer, S. Grochowski, R. B. Hyman // Schizophr. Res. – 1995. – Vol. 14. – P. 229–234.Barnes T. R. E., Liddle Evidense for the valibity of negative symptos. Scizophrenia: Positive and negative Symptoms and Syndroms. Modern Problems in Pharmacopsychiatry. Andreasen N. S., Kargen, Basel1990. vol. 24. p. 43–72.Barnes T. R. E., Liddle Evidense for the valibity of negative symptos. Scizophrenia: Positive and negative Symptoms and Syndroms. Modern Problems in Pharmacopsychiatry. Andreasen N. S., Kargen, Basel1990. vol. 24. p. 43–72.Минутко В. Л. (2009) Шизофрения: монография. Курск, 2009, стр. 164–168.Минутко В. Л. (2009) Шизофрения: монография. Курск, 2009, стр. 164–168.Brüne M. The incidence of akathisia in bipolar affective disorder treated with neurolepticsa preliminary report (1999). J Affect Disord. Vol. 53, no. 2, pp. 175–177. Availabe: https://www.ncbi.nlm.nih.gov/pubmed/10360412.Brüne M. The incidence of akathisia in bipolar affective disorder treated with neurolepticsa preliminary report (1999). J Affect Disord. Vol. 53, no. 2, pp. 175–177. Availabe: https://www.ncbi.nlm.nih.gov/pubmed/10360412.Joukamaa M., Heliovaara M., Knekt P. (2006) Schizophrenia, neuroleptic medication and mortality. British Journal of Psychiatry. Vol. 188, рр. 122–127.Joukamaa M., Heliovaara M., Knekt P. (2006) Schizophrenia, neuroleptic medication and mortality. British Journal of Psychiatry. Vol. 188, рр. 122–127.Stahl S. M., Lonnen A. J. The Mechanism of Druginduced Akathisia. CNS Spectr. 2011. pii:Stahl.Stahl S. M., Lonnen A. J. The Mechanism of Druginduced Akathisia. CNS Spectr. 2011. pii:Stahl.Lohr J. B., Eidt C. A., Abdulrazzaq Alfaraj A. et al. (2015) The clinical challenges of akathisia. CNS Spectr. Vol. 20, pp. 15–16 Availabe: https://www.ncbi.nlm.nih.gov/pubmed/26683525.Lohr J. B., Eidt C. A., Abdulrazzaq Alfaraj A. et al. (2015) The clinical challenges of akathisia. CNS Spectr. Vol. 20, pp. 15–16 Availabe: https://www.ncbi.nlm.nih.gov/pubmed/26683525.

The authors declare that there are no conflicts of interest present.