milmedВоенная медицинаMilitary Medicine2074-5044Белорусский государственный медицинский университетmilmed-562Research ArticleОРИГИНАЛЬНЫЕ НАУЧНЫЕ ПУБЛИКАЦИИ. Лечебно-профилактические вопросыORIGINAL SCIENTIFIC PUBLICATIONS. Medical and preventive questionsЭкспериментальные модели атопического дерматитаExperimental models of atopic dermatitisСымановичО. Ю.SymanovichV. U.ГончаровА. Е.HancharouA. Y.ХватоваЛ. А.KhvatovaL. A.УО «Белорусский государственный медицинский университет»BelarusРНПЦ эпидемиологии и микробиологииBelarus201821102026027577Copyright © Сыманович О.Ю., Гончаров А.Е., Хватова Л.А., 20262026Сыманович О.Ю., Гончаров А.Е., Хватова Л.А.Symanovich V.U., Hancharou A.Y., Khvatova L.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://milmed.ejournal.by/jour/article/view/562

Рассмотрена актуальность и необходимость применения экспериментальных моделей атопического дерматита на животных, а также основные проблемы, связанные с его моделированием in vivo. Проанализированы существующие экспериментальные модели атопического дерматита, а также возможные преимущества и недостатки каждой из них в зависимости от поставленных целей и задач исследования. Наиболее детально рассмотрена комбинированная модель атопического дерматита, сочетающая генетическую предрасположенность, нарушение барьерной функции кожи (механическое и химическое повреждение) и воздействие аллергена (путем многократной сенсибилизации). Для индукции атопии, в зависимости от поставленных задач исследования, могут быть применены – гаптены, чужеродные белки (овальбумин), а также наиболее часто встречающиеся в данном регионе аллергены (например, на пылевых клещей Dermatophagoides farinae).

Actuality and necessity of using of experimental models of atopic dermatitis on animals and the main problems, associated with its modeling in vivo, were investigated. The existing experimental models were analyzed as well as possible advantages and disadvantages of each of them, depending on the goals and objectives of the study. The model of atopic dermatitis, with a combination of a genetic predisposition with the destruction of the border function of skin (mechanical and chemical disruption) and applications of allergen (with using of repeated sensitization), was learnt in the details. For induction of atopic reaction, depending on assigned tasks of investigation, haptens, foreign proteins (ovalbumin), as well as the most common allergens in the region (for example, on dust mites Dermatophagoides farinae) may be used.

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The authors declare that there are no conflicts of interest present.