milmedВоенная медицинаMilitary Medicine2074-5044Белорусский государственный медицинский университетmilmed-590Research ArticleОРИГИНАЛЬНЫЕ НАУЧНЫЕ ПУБЛИКАЦИИ. Лечебно-профилактические вопросыORIGINAL SCIENTIFIC PUBLICATIONS. Medical and preventive questionsПрогностические факторы выживаемости паратиреоидного клеточного аллотрансплантатаPrognostic factors of cellular parathyroid allograft survivalХрыщановичВ. Я.KhryshchanovichV. Y.ГУО «Белорусская медицинская академия последипломного образования»Belarus201822102026034751Copyright © Хрыщанович В.Я., 20262026Хрыщанович В.Я.Khryshchanovich V.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://milmed.ejournal.by/jour/article/view/590

Исследование посвящено установлению прогностических факторов выживаемости паратиреоидного клеточного аллотрансплантата у 19 реципиентов с гипопаратиреозом. Была изучена взаимосвязь между длительностью функционирования аллотрансплантата и возрастом донора и реципиента, длительностью гипопаратиреоза, количеством трансплантированных паратироцитов, концентрацией сывороточного паратгормона до пересадки. Использование для пересадки гиперплазированной паратиреоидной ткани, полученной от доноров с высокими показателями сывороточного паратгормона (≥500 пг/мл), анамнез гипопаратиреоза ≥5 лет, дооперационная концентрация сывороточного паратгормона <15 пг/мл и пересадка не менее 8 миллионов паратироцитов способствовали наибольшей (>6 месяцев) продолжительности функционирования паратиреоидного аллотрансплантата.

The aim of the study was detected of prognostic factors of cellular parathyroid allograft survival. The relationship between duration of allograft functioning and age of donors and recipients, duration of hypoparathyroidism, amount of transplanted parathyroid cells, serum parathyroid hormone levels before transplantation were studied. Hyperplastic parathyroid tissue, obtained from donors with high parathyroid hormone levels (≥500 pg/ml), duration of hypoparathyroidism more than 5 years, parathyroid hormone serum level before transplantation less than 15 pg/ml, grafting not less than 8 million parathyroid cells contributed to the greatest (>6 months) duration of parathyroid allograft functioning.

гипопаратиреозпаратироцитыаллотрансплантацияhypoparathyroidismparathyroid cellsallotransplantationReferencesHypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research / J. P. Bilezikian [et al.] // J. Bone Min. Res. – 2011. – Vol. 26, № 10. – P. 2317–2337.Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research / J. P. Bilezikian [et al.] // J. Bone Min. Res. – 2011. – Vol. 26, № 10. – P. 2317–2337.Halsted, W. S. Hypoparathyreosus, status parathyreoprivus and transplantation of the parathyroid glands / W. S. Halsted // Amer. J. Med. Sci. – 1907. – Vol. 1. – P. 134.Halsted, W. S. Hypoparathyreosus, status parathyreoprivus and transplantation of the parathyroid glands / W. S. Halsted // Amer. J. Med. Sci. – 1907. – Vol. 1. – P. 134.Bloom, A. D. Indefinite survival of rat parathyroid allografts without postoperative immunosuppression / A. D. Bloom, S. G. Economou, H. M. Hebel // Surgery. – 1986. – Vol. 100, № 6. – P. 1032–1038.Bloom, A. D. Indefinite survival of rat parathyroid allografts without postoperative immunosuppression / A. D. Bloom, S. G. Economou, H. M. Hebel // Surgery. – 1986. – Vol. 100, № 6. – P. 1032–1038.Allotransplantation of rat parathyroid glands: effects of organ culture and transplantation into the adrenal gland / S. C. Kukreja [et al.] // Experientia. – 1979. – Vol. 35, № 4. – P. 559–560.Allotransplantation of rat parathyroid glands: effects of organ culture and transplantation into the adrenal gland / S. C. Kukreja [et al.] // Experientia. – 1979. – Vol. 35, № 4. – P. 559–560.Bromberg, J. S. Routes to allograft survival / J. S. Bromberg, B. Murphy // J. Clin. Invest. – 2001. – Vol. 107, № 7. – P. 797–798.Bromberg, J. S. Routes to allograft survival / J. S. Bromberg, B. Murphy // J. Clin. Invest. – 2001. – Vol. 107, № 7. – P. 797–798.Naji, A. Effect of culture in 95% O2 on the survival of parathyroid allografts / A. Naji, W. Silvers, C. Barker // Surg. Forum. − 1979. – Vol. 30. – P. 109.Naji, A. Effect of culture in 95% O2 on the survival of parathyroid allografts / A. Naji, W. Silvers, C. Barker // Surg. Forum. − 1979. – Vol. 30. – P. 109.Short-term immunosuppression after rat parathyroid allotransplantation / S. Timm [et al.] // Microsurgery. – 2003. – Vol. 23, № 5. – P. 503–507.Short-term immunosuppression after rat parathyroid allotransplantation / S. Timm [et al.] // Microsurgery. – 2003. – Vol. 23, № 5. – P. 503–507.Allotransplantation of cultured parathyroid progenitor cells without immunosuppression: clinical results / I. Nawrot [et al.] // Transplantation. – 2007. – Vol. 83, № 6. – P. 734–740.Allotransplantation of cultured parathyroid progenitor cells without immunosuppression: clinical results / I. Nawrot [et al.] // Transplantation. – 2007. – Vol. 83, № 6. – P. 734–740.Cultured parathyroid cells allotransplantation without immunosuppression for treatment of intractable hypoparathyroidism / T. Tolloczko [et al.] // Ann. Transplant. – 1996. – Vol. 1. – P. 51–53.Cultured parathyroid cells allotransplantation without immunosuppression for treatment of intractable hypoparathyroidism / T. Tolloczko [et al.] // Ann. Transplant. – 1996. – Vol. 1. – P. 51–53.Rossini, A. A. Induction of immunologic tolerance for transplantation / A. A. Rossini, D. L. Greiner, J. P. Mordes // Physiol. Rev. – 1999. – Vol. 79, № 1. – P. 99–141.Rossini, A. A. Induction of immunologic tolerance for transplantation / A. A. Rossini, D. L. Greiner, J. P. Mordes // Physiol. Rev. – 1999. – Vol. 79, № 1. – P. 99–141.Human parathyroid grafts survived and functioned in mice treated with anti-CD4 monoclonal antibody / M. Niimi [et al.] // Transpl. Proc. – 2000. – Vol. 32. – P. 1040.Human parathyroid grafts survived and functioned in mice treated with anti-CD4 monoclonal antibody / M. Niimi [et al.] // Transpl. Proc. – 2000. – Vol. 32. – P. 1040.Subtotal parathyroidectomy in renal failure: still needed after all these years / P. A. Decker [et al.] // World J. Surg. – 2001. – Vol. 25. – P. 708–712.Subtotal parathyroidectomy in renal failure: still needed after all these years / P. A. Decker [et al.] // World J. Surg. – 2001. – Vol. 25. – P. 708–712.Харламова, А. Н. Особенности длительного культивирования клеток паращитовидной железы человека / А. Н. Харламова, В. Я. Хрыщанович, С. И. Третьяк // Военная медицина. – 2014. – № 1. – С. 106–109.Харламова, А. Н. Особенности длительного культивирования клеток паращитовидной железы человека / А. Н. Харламова, В. Я. Хрыщанович, С. И. Третьяк // Военная медицина. – 2014. – № 1. – С. 106–109.Thyroid allograft immunogenicity is reduced after a period in organ culture / K. J. Lafferty [et al.] // Science. – 1975. – Vol. 188. – P. 259–261.Thyroid allograft immunogenicity is reduced after a period in organ culture / K. J. Lafferty [et al.] // Science. – 1975. – Vol. 188. – P. 259–261.Survival of macroencapsulated allogeneic parathyroid tissue one year after transplantation in non-immunosuppressed humans / A. Tibell [et al.] // Cell Transplant. – 2001. – Vol. 10 (7). – P. 591–599.Survival of macroencapsulated allogeneic parathyroid tissue one year after transplantation in non-immunosuppressed humans / A. Tibell [et al.] // Cell Transplant. – 2001. – Vol. 10 (7). – P. 591–599.Allotransplantation of cultured human parathyroid cells: present status and perspectives / T. Tolloczko [et al.] // Transplant Proc. – 1997. – Vol. 29. – P. 998–1000.Allotransplantation of cultured human parathyroid cells: present status and perspectives / T. Tolloczko [et al.] // Transplant Proc. – 1997. – Vol. 29. – P. 998–1000.

The authors declare that there are no conflicts of interest present.