References

milmed

Военная медицина

Military Medicine

2074-5044

Белорусский государственный медицинский университет

milmed-713

Research Article

ОРИГИНАЛЬНЫЕ НАУЧНЫЕ ПУБЛИКАЦИИ. Лечебно-профилактические вопросы

ORIGINAL SCIENTIFIC PUBLICATIONS. Medical and preventive questions

Ранние нарушения эластических свойств аорты как маркер развития аортопатии у пациентов с двустворчатым аортальным клапаном

Early disturbances elastic properties of the aorta as marker of aortopatii in patients with bicuspid aortic valve

Рудой

А. С.

Rudoy

А. S.

Бова

А. А.

Bova

A. A.

Валюженич

Я. И.

Valiuzhenich

Y. I.

Урываев

А. М.

Uryvaev

A. M.

Хотько

Н. Г.

Hotko

N. G.

Военно-медицинский факультет в УО «Белорусский государственный медицинский университет»BelarusГУ «432 ордена Красной Звезды главный военный клинический медицинский центр Вооруженных Сил Республики Беларусь»Belarus

2019

24102026

036873

2026

Рудой А.С., Бова А.А., Валюженич Я.И., Урываев А.М., Хотько Н.Г.

Rudoy А.S., Bova A.A., Valiuzhenich Y.I., Uryvaev A.M., Hotko N.G.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://milmed.ejournal.by/jour/article/view/713

Известно, что пациенты с двустворчатым аортальным клапаном (ДАК), в том числе без гемодинамических нарушений на клапане, склонны к развитию дилатации и расслоению корня и восходящего отдела аорты по сравнению с лицами соответствующего возраста и пола, имеющими трехстворчатый аортальный клапан (ТАК). Низкая прогностическая ценность применяемых на сегодняшний день биомаркеров риска развития диссекции аорты обуславливает поиск новых методов диагностики ранних проявлений ДАК-ассоциированной аортопатии. Целью исследования явилась оценка эластических свойств аорты у пациентов с ДАК методом двухмерной спекл-трекинг эхокардиографии (впервые предложенным нами в Республике Беларусь в качестве инструмента оценки функции аорты) у пациентов с ДАК с дилатацией аорты и без в сравнении с пациентами с ТАК. Обследовано 47 пациентов (22 пациента с ДАК, средний возраст 44 года; 25 здоровых добровольцев, средний возраст 44 года). Установлено, что у пациентов с ДАК в 100% случаев имеется ассоциированная аортопатия, характеризующаяся увеличением размеров корня аорты на всех анатомических уровнях (преимущественно в синотубулярном гребне), сопровождаясь в каждом ¼ случае дилатацией стенки аорты. В качестве раннего маркера развития ДАК-ассоциированной аортопатии с нарушением эластических свойств аорты может служить снижение глобальной циркулярной деформации (9,8 (1,7) % vs 7,64 (3,9) %; p = 0,01) на фоне увеличенных показателей растяжимости и жесткости аорты.

Patients with bicuspid aortic valve (BAV), including without hemodynamic disorders prone to the development of dilatation and dissection of the root and ascending aorta compared with patients with tricuspid aortic valve. The low prognostic value of currently used biomarkers of the risk of developing aortic dissection leads to the search for new methods for diagnosing early manifestations of BAV-associated aortopathy. The aim of the study was to evaluate the elastic properties of the aorta in patients with BAV using the method of two-dimensional speckle tracking echocardiography (first proposed in the Republic of Belarus as an instrument for assessing aortic function) in patients with BAV and aortic dilatation and without compared with patients with tricuspid aortic valve (TAV).47 patients were examined (22 patients with BAV, mean age 44 years, 25 volunteers, mean age 44 years).BAV-associated aortopathy was found in 100% of cases, characterized by an increase in aortic root size at all anatomical levels (mainly in the synotubular junction), accompanied in each case by dilatation of the aortic wall.As an early marker for the development of BAV-associated aortopathy with a violation of the elastic properties of the aorta, a reduction in global circular deformation (9.8 (1.7)% vs 7.64 (3.9)%; p = 0.01) against the background of increased indicators of distensibility and stiffness of the aorta.

Двустворчатый аортальный клапанДАК-ассоциированная аортопатияаневризма аортыдвухмерная спекл-трекинг эхокардиографиярастяжимостьиндекс жесткости

bicuspid aortic valveBAV-associated aortopathyaortic aneurysmtwo-dimensional speckle-tracking echocardiographydistensibilitystiffness index

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The authors declare that there are no conflicts of interest present.