milmedВоенная медицинаMilitary Medicine2074-5044Белорусский государственный медицинский университетmilmed-719Research ArticleОРИГИНАЛЬНЫЕ НАУЧНЫЕ ПУБЛИКАЦИИ. Новые технологии в медицинеORIGINAL SCIENTIFIC PUBLICATIONS. New technologies in medicineГалектин-3 – маркер аневризматической трансформации при дак-ассоциированной аортопатииGalectin-3 is a marker of aneurysmal transformation in bav-associated aortopathyРудойА. С.RudoyА. S.БоваА. А.BovaA. A.ВалюженичЯ. И.ValiuzhenichY. I.УрываевА. М.UryvaevA. M.Военно-медицинский факультет в УО «Белорусский государственный медицинский университет»Belarus2019241020260395100Copyright © Рудой А.С., Бова А.А., Валюженич Я.И., Урываев А.М., 20262026Рудой А.С., Бова А.А., Валюженич Я.И., Урываев А.М.Rudoy А.S., Bova A.A., Valiuzhenich Y.I., Uryvaev A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://milmed.ejournal.by/jour/article/view/719

Двустворчатый аортальный клапан (ДАК) – один из самых распространенных и гетерогенных врожденных пороков сердца, затрагивающий примерно 0,5–2% популяции населения, часто проявляющийся ассоциированной аортопатией.Научный интерес представляет поиск новых биомаркеров, отражающих патофизиологический процесс в сосудистой стенке и имеющих предсказательную роль для прогноза дилатации и профилактики жизнеугрожающих осложнений. Целью исследования явилось уточнение предикторной роли галектина-3 в качестве потенциального биомаркера аневризматической трансформации ДАК-ассоциированной аортопатии. Обследовано 47 пациентов (22 пациента с ДАК, средний возраст 44 года; 25 здоровых добровольцев, средний возраст 44 года). Измерение сывороточного уровня галектина-3 проводилось с помощью иммуноферментного анализа (Galectin 3 ELISA Kit).Установлено, что повышенный уровень галектина-3 в сыворотке крови у пациентов с ДАК-ассоциированной аортопатией может служить серологическим маркером неблагоприятного прогноза в виде нарушения адаптационных свойств стенки аорты с увеличением размеров диаметра аорты.

Bicuspid aortic valve (BAV) is one of the most common and heterogeneous congenital heart diseases, affecting approximately 0.5–2% of the population, often manifested by associated aortopathy. Of scientific interest is the search for new biomarkers reflecting the pathophysiological process in the vascular wall as a prediction of its dilatation in order to prevent a life-threatening condition.The aim of the study was to clarify the predictive role of galectin-3 as a potential biomarker of the aneurysmal transformation of BAV-associated aortopathy.47 patients were examined (22 patients with BAV, mean age 44 years; 25 volunteers, mean age 44 years). The measurement of the serum level of galectin-3 was carried out using an ELISA kit (Galectin 3 ELISA Kit). It has been established that an increased serum level of galectin-3 in patients with BAV-associated aortopathy may serve as a serological marker indicating a poor prognosis, accompanied by an increase in the size of the aorta diameter.

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The authors declare that there are no conflicts of interest present.