References

milmed

Военная медицина

Military Medicine

2074-5044

Белорусский государственный медицинский университет

milmed-751

Research Article

ОБЗОРЫ И ЛЕКЦИИ

REVIEWS AND LECTURES

Алкоголь и шизофрения: грани взаимодействия

Alcohol and schizophrenia: facets of interaction

Хмара

Н. В.

Hmara

N. V.

Скугаревский

О. А.

Skugarevsky

O. A.

УО «Гомельский государственный медицинский университет»BelarusУО «Белорусский государственный медицинский университет»Belarus

2019

25102026

049498

2026

Хмара Н.В., Скугаревский О.А.

Hmara N.V., Skugarevsky O.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://milmed.ejournal.by/jour/article/view/751

Приведенный литературный обзор описывает основные принятые модели, объясняющие причины употребление алкоголя лицами с шизофренией, рассмотрены их недостатки и преимущества. На основании данных литературы, выявлено влияние алкоголя на психопатологические симптомы, когнитивные функции и исполнительские когниции у лиц с шизофренией на разных этапах потребления. Установлена недостаточная изученность влияния доклинических форм употребления алкоголя на течение, исход заболевания и такой эффект, как проявление агрессии.

This literature review describes the main accepted models that explain the causes of alcohol use by people with schizophrenia, their disadvantages and advantages are considered. Based on literature data, the influence of alcohol on psychopathological symptoms, cognitive functions and performing cognition in people with schizophrenia at different stages of consumption was revealed. Insufficient knowledge of the influence of preclinical forms of alcohol consumption on the course, outcome of the disease and such an effect as the manifestation of aggression has been established.

шизофренияалкоголькогнитивные функцииисполнительские когницииагрессия

schizophreniaalcoholcognitive functionsperforming cognitionaggression

References1

ВОЗ | Употребление с риском вредных последствий // WHO. World Health Organization, 2012.

Addington J., Addington, D. Substance abuse and cognitive functioning in schizophrenia // Journal of Psychiatry and Neuroscience. – 1997. – Т. 22. – № 2. – С. 99.

Addington, J., Duchak, V. Reasons for substance use in schizophrenia // Acta Psychiatrica Scandinavica. – 1997. – Т. 96. – № 5. – С. 329–333.

Barnes, T. R. E. et al. Comorbid substance use and age at onset of schizophrenia // The British Journal of Psychiatry. – 2006. – Т. 188. – № 3. – С. 237–242.

Bizzarri, J. V. et al. Substance use in severe mental illness: self-medication and vulnerability factors // Psychiatry research. – 2009. – Т. 165. – № 1–2. – С. 88–95.

Blanchard, J. J. et al. Substance use disorders in schizophrenia: review, integration, and a proposed model // Clinical psychology review. – 2000. – Т. 20. – № 2. – С. 207–234.

Bowie C. R., Harvey P. D. Cognition in schizophrenia: impairments, determinants, and functional importance // Psychiatric Clinics. – 2005. – Т. 28. – № 3. – С. 613–633.

Carrà, G. et al. Psychosocial functioning, quality of life and clinical correlates of comorbid alcohol and drug dependence syndromes in people with schizophrenia across Europe // Psychiatry research. – 2016. – Т. 239. – С. 301–307.

Dervaux, A. et al. Impulsivity and sensation seeking in alcohol abusing patients with schizophrenia // Frontiers in psychiatry. – 2010. – Т. 1. – С. 135.

D’Souza, D. C. et al. Enhanced sensitivity to the euphoric effects of alcohol in schizophrenia // Neuropsychopharmacology. – 2006. – Т. 31. – № 12. – С. 2767–2775.

Drake R. E., Osher F. C., Wallach M. A. Alcohol use and abuse in schizophrenia: a prospective community study // Journal of Nervous and Mental Disease. – 1989. – T. 177. – C. 408–414.

Dry, M. J. et al. Dose-Related Effects of Alcohol on Cognitive Functioning // PLoS ONE. – 2012. – Т. 7. – № 11.

Fernandez-Serrano M. J. et al. Neuropsychological consequences of alcohol and drug abuse on different components of executive functions // Journal of psychopharmacology. – 2010. – Т. 24. – № 9. – С. 1317–1332.

Goswami, S. et al. Substance-abusing schizophrenics: do they self-medicate? // The American Journal on Addictions. – 2004. – Т. 13. – № 2. – С. 139–150.

Gouzoulis-Mayfrank E. Dual diagnosis of psychosis and addiction. From principles to practice // Der Nervenarzt. – 2004. – Т. 75. – № 7. – С. 642–650.

Graham, H. L. The role of dysfunctional beliefs in individuals who experience psychosis and use substances: implications for cognitive therapy and medication adherence // Behavioural and Cognitive Psychotherapy. – 1998. – Т. 26. – № 3. – С. 193–208.

Green, A. I. et al. First episode schizophrenia-related psychosis and substance use disorders: acute response to olanzapine and haloperidol // Schizophrenia Research. – 2004. – Т. 66. – № 2–3. – С. 125–135.

Gregg, L., Barrowclough, C., Haddock, G. Reasons for increased substance use in psychosis // Clinical psychology review. – 2007. – Т. 27. – № 4. – С. 494–510.

Harrison, I. et al. Naturalistic follow-up of co-morbid substance use in schizophrenia: the West London firstepisode study // Psychological medicine. – 2008. – Т. 38. – № 1. – С. 79–88.

Hartz, S. M. et al. Comorbidity of severe psychotic disorders with measures of substance use // JAMA psychiatry. – 2014. – Т. 71. – № 3. – С. 248–254.

Hjorthøj, C. et al. Association between alcohol and substance use disorders and all-cause and cause-specific mortality in schizophrenia, bipolar disorder, and unipolar depression: a nationwide, prospective, register-based study // The Lancet Psychiatry. – 2015. – Т. 2. – № 9. – С. 801–808.

Hodgins, S., Piatosa, M. J., Schiffer, B. Violence among people with schizophrenia: phenotypes and neurobiology // Neuroscience of aggression. – Springer, Berlin, Heidelberg, 2013. – С. 329–368.

Kerner, B. Comorbid substance use disorders in schizophrenia: a latent class approach // Psychiatry research. – 2015. – Т. 225. – № 3. – С. 395–401.

Khantzian, E. J. The self-medication hypothesis of substance use disorders: A reconsideration and recent applications // Harvard review of psychiatry. – 1997. – Т. 4. – № 5. – С. 231–244.

Kraus, L. et al. Association of average daily alcohol consumption, binge drinking and alcohol-related social problems: Results from the German Epidemiological Surveys of Substance Abuse // Alcohol & Alcoholism. – 2009. – Т. 44. – № 3. – С. 314–320.

Krystal, J. H. et al. The vulnerability to alcohol and substance abuse in individuals diagnosed with schizophrenia // Neurotoxicity research. – 2006. – Т. 10. – № 3–4. – С. 235–252.

Kendler, K. S. et al. Lifetime prevalence, demographic risk factors, and diagnostic validity of nonaffective psychosis as assessed in a US community sample: the National Comorbidity Survey // Archives of general psychiatry. – 1996. – Т. 53. – № 11. – С. 1022–1031.

Laursen, T. M., Munk-Olsen T., Vestergaard M. Life expectancy and cardiovascular mortality in persons with schizophrenia // Current opinion in psychiatry. – 2012. – Т. 25. – № 2. – С. 83–88.

Lau, S. et al. Latent class analysis identified phenotypes in individuals with schizophrenia spectrum disorder who engage in aggressive behaviour towards others // European Psychiatry. – 2019. – Т. 60. – С. 86–96.

Manning, V. et al. Screening for cognitive functioning in psychiatric outpatients with schizophrenia, alcohol dependence, and dual diagnosis // Schizophrenia research. – 2007. – Т. 91. – № 1–3. – С. 151–158.

Manning, V. et al. Cognitive impairment in dual diagnosis inpatients with schizophrenia and alcohol use disorder // Schizophrenia Research. – 2009. – Т. 114. – № 1–3. – С. 98–104.

Margolese, H. C. et al. Drug and alcohol use among patients with schizophrenia and related psychoses: levels and consequences // Schizophrenia research. – 2004. – Т. 67. – № 2–3. – С. 157–166.

Mueser, K. T., Drake, R. E., Wallach, M. A. Dual diagnosis: a review of etiological theories // Addictive behaviors. – 1998. – Т. 23. – № 6. – С. 717–734.

Mueser K. T. et al. Substance use disorder in hospitalized severely mentally ill psychiatric patients: prevalence, correlates, and subgroups // Schizophrenia Bulletin. – 2000. – Т. 26. – № 1. – С. 179–192.

Pierce, R. C., Kumaresan, V. The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse? // Neuroscience & biobehavioral reviews. – 2006. – Т. 30. – № 2. – С. 215–238.

Rodriguez-Jimenez, R. et al. Executive function in schizophrenia: influence of substance use disorder history // Schizophrenia research. – 2010. – Т. 118. – № 1–3. – С. 34–40.

Rossow, I., Romelsjö, A. The extent of the ‘prevention paradox’in alcohol problems as a function of population drinking patterns // Addiction. – 2006. – Т. 101. – № 1. – С. 84–90.

Reinharth, J. et al. Cognitive predictors of violence in schizophrenia: a meta-analytic review // Schizophrenia Research: Cognition. – 2014. – Т. 1. – № 2. – С. 101–111.

Salyers, M. P., Mueser K. T. Social functioning, psychopathology, and medication side effects in relation to substance use and abuse in schizophrenia // Schizophrenia research. – 2001. – Т. 48. – № 1. – С. 109–123.

Spencer, C., Castle, D., Michie, P. T. Motivations that maintain substance use among individuals with psychotic disorders // Schizophrenia Bulletin. – 2002. – Т. 28. – № 2. – С. 233.

Swofford, C. D. et al. Substance use: a powerful predictor of relapse in schizophrenia // Schizophrenia research. – 1996. – Т. 20. – № 1–2. – С. 145–151.

Talamo, A. et al. Comorbid substance-use in schizophrenia: relation to positive and negative symptoms // Schizophrenia research. – 2006. – Т. 86. – № 1–3. – С. 251–255.

Thoma, P., Daum, I. Working memory and multitasking in paranoid schizophrenia with and without comorbid substance use disorder // Addiction. – 2008. – Т. 103. – № 5. – С. 774–786.

Thoma, P., Wiebel, B., Daum, I. Response inhibition and cognitive flexibility in schizophrenia with and without comorbid substance use disorder // Schizophrenia research. – 2007. – Т. 92. – № 1–3. – С. 168–180.

Tsai, J., Rosenheck, R. A. Psychiatric comorbidity among adults with schizophrenia: A latent class analysis // Psychiatry research. – 2013. – Т. 210. – № 1. – С. 16–20.

Witt, K., van Dorn R., Fazel S. Risk Factors for Violence in Psychosis: Systematic Review and Meta-Regression Analysis of 110 Studies // PLoS ONE. – 2013. – Т. 8. – № 2.

The authors declare that there are no conflicts of interest present.