milmedВоенная медицинаMilitary Medicine2074-5044Белорусский государственный медицинский университетmilmed-859Research ArticleОРИГИНАЛЬНЫЕ НАУЧНЫЕ ПУБЛИКАЦИИ. Лечебно-профилактические вопросыORIGINAL SCIENTIFIC PUBLICATIONS. Medical and preventive questionsК вопросу о выявлении возбудителя Mycoplasma hominis у амбулаторных пациентов и о рекомендациях по рациональной антибиотикотерапииSome issues of detection of mycoplasma hominis in outpatient patients and recommendations for rational antibiotic therapyХилькевичН. Д.KhilkevichM. D.СухобоковаН. Н.SukhobokovaN. N.ШарайМ. Р.SharaiM. R.УО «Белорусский государственный медицинский университет»BelarusУЗ «Городской клинический кожно-венерологический диспансер»Belarus202028102026036570Copyright © Хилькевич Н.Д., Сухобокова Н.Н., Шарай М.Р., 20262026Хилькевич Н.Д., Сухобокова Н.Н., Шарай М.Р.Khilkevich M.D., Sukhobokova N.N., Sharai M.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://milmed.ejournal.by/jour/article/view/859

Проведено исследование 27 429 анализов у амбулаторного контингента пациентов, включая мужчин и женщин, обратившихся для обследования на инфекции, передаваемые половым путем. Положительные результаты на выявление возбудителя М. hominis получены в 5,1%, из которых доля моно-инфекции составила 0,3%, сочетанной с U. urealyticum – 4,8%. На протяжении 9-летнего наблюдения отмечена статистически значимая тенденция к уменьшению выявления инфекции М. hominis среди указанной категории пациентов. Частота обнаружения «патологической» контаминации (> 104 КОЕ/мл) составила в случае моно-инфекции 6,3%, в сочетании с U. urealyticum 9,1%. Статистически достоверных различий, свидетельствующих о взаимном отягощающем влиянии сочетания двух микоплазменных возбудителей, не выявлено (р > 0,05). Препаратами выбора в лечении инфекции M. hominis следует считать антибиотики тетрациклинового ряда и фторхинолоны, показавшие наилучшие результаты лабораторного тестирования. Для лечения беременных и детей можно рекомендовать джозамицин. Лечение показано, главным образом, пациентам с клиническими признаками воспалительного процесса.

A study of 27,429 specimens was conducted in an outpatient population of patients, including men and women who applied for examination for sexually transmitted infections. Positive results for the detection of the pathogen M. hominis were obtained in 5.1%, of which the proportion of mono-infection was 0.3%, combined with U. urealyticum – 4.8%. During the 9-year follow-up, there was a statistically significant tendency to reduction of the detection of M. hominis infection among this category of patients. The detection rate of «pathological» contamination (> 104 CFU/ml) was 6.3% in case of mono-infection, in combination with U. urealyticum 9.1%. There were no statistically significant differences indicating a mutual aggravating effect of the combination of two Mycoplasma pathogens (p > 0.05). Tetracycline antibiotics and fluoroquinolones, which have shown the best results of laboratory testing, should be considered the drugs of choice in the treatment of M. hominis infection. For the treatment of pregnant women and children, josamycin can be recommended. Treatment is indicated mainly for patients with clinical signs of inflammation.

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The authors declare that there are no conflicts of interest present.