Characteristic changes in immune resistance in patients with unspecific vertebral infection
https://doi.org/10.51922/2074-5044.2026.2.16
Abstract
The work is based on the study of the immunograms of 56 patients with a vertebral infection (non-specific spinal osteomyelitis – M46.3, spinal epidural abscess G06.1) and 30 practically healthy volunteers. Patients were divided into 2 subgroups depending on the presence of paravertebral septic complications. It was found that there is a correlation of different strength between the level of immune complexes and biochemical markers of inflammation. According to different indicators, the degree of deficiency or excess of cellular and humoral immunity factors was calculated, a rating algorithm was compiled by the diagnostic significance factor and the status of the immune system in complicated and uncomplicated forms of infection was determined, that will further help in the development of appropriate immunomodulatory therapy.
About the Authors
A. V. Kornilov
Vitebsk State Medical University
Belarus
Belarus
Vitebsk
S. A. Alexeev
Belarusian State Medical University
Belarus
Belarus
Minsk
S. V. Bontsevich
Vitebsk City Clinical Hospital of Emergency Medical Care
Belarus
Belarus
Vitebsk
M. V. Kuncevich
Vitebsk State Medical University
Belarus
Belarus
Vitebsk
K. S. Vykhrystsenka
Vitebsk State Medical University
Belarus
Belarus
Vitebsk
E. A. Matusevich
Vitebsk Regional Clinical Hospital
Belarus
Belarus
Vitebsk
References
1. Kazmirchuk, V. E., Kovalchuk, L. V., Maltsev, D. V. Clinical immunology and allergology. // Kazmirchuk V. E., Kovalchuk JI. B., Maltsev D. V. -K.: Fenix, 2009 – 524 p.
2. Ageyev, T. S. Mishustyna, E. L. Tetenev, F. F. Dubdelova, A. V. Meshko, P. E. Tetenev, K. F. Clinical interpretation of the analysis of peripheral blood: a training manual / T. S. Aheeva, E. L. Mishustina, F. F. Tetenev et al. – Tomsk: SibGMU, 2014. – 72 c.
3. Yasetz, U. I. Interpretation of the results of immunograms / J. I. Yasetz, – Gomel: General Counsel «RMPC RMIEC», 2020. – 38 p.
4. Current diagnosis and treatment of spondylodiscitis / R. Sobottke [et al.] // Dtsch. Arztebl. Int. – 2008 Mar. – Vol. 105, N 10. – P. 181–187.
5. Clinical recommendations for diagnosis and treatment of inflammatory diseases of the spine and spinal cord / Association of neurosurgeons of Russia. – M., 2015. – 34 p.
6. Goncharov, M. Y. The provision of specialized neurosurgical assistance to patients with non-specific purulent spinal diseases in a large industrial region/ M. Y. Goncharov, E. Y. Levzyk // Bыл. WCNC CO RAMN. – 2011. – 4, ch. 1. – S. 307–310.
7. Timofeev, S. A., Vishnievsky, A. A. Distant results of surgical treatment of non-specific osteomyelitis // Spinal surgery. 2007. 1. p. 52–59.
8. Goncharov, M. Y. Systemic inflammatory response syndrome in the surgical treatment of non-specific spinal septic diseases/ M. Y. Goncharov, V. P. Sakovitch, E. Y. Levczyk // Bull. WCNC CO RAMN. – 2012. – 4. – P. 39–42.
9. Gavriluk, V. P., Statina, M. I., Severinov, D. A., Mashoshina, L. O. Immune and metabolic disorders in hematogenic osteomyelitis in children // Vyatsky medical herald. 2022. 1 (73).
10. Chepeleva Marina Vladimirovna, Klušin Nikolay Mikhailovich Immunological features of chronic post-traumatic osteomyelitis // Traumatology and orthopedics of Russia. 2012. 2.
11. Guarulov, A. V., Zemskov, A. M., Zemskov, V. M. Clinical Immunology and Allergology: Teaching Manual / Under Red. A. Karalova – M.: Medical information agency, 2002 – 651 p.
12. Vojno-Yazenetsky, V. F. (Archbishop Luka) Outlines of the Gnosis Surgery. – M. – SpB.: ZAO «Publishing BINON», «Newhsk Dialect», 2000 – 704 p.
13. Kornilov, N. V. Adaptation processes in skeletal organs / N. V. Kornilov, A. S. Avrunin. – SPb., 2001. – 296 p.
14. Belochvostikova, T. S. Immunological control of inflammation and regeneration of bone tissue in chronic osteomyelitisи/ T. S. Belochvostikova, J. S. Vinnik, S. N. Leonova – Novosibirsk: Science, 2009 – 160 s.
15. Zemskov, A. M. Directory of operational information on clinical immunology and allergology for medical students. - Doctors and Hospital Physicians, [2 h.] / A. M. Zemskov, V. M. Zemskov; International Academy of Sciences et al. – 2nd edition., pp. – Voronezh: WGMA, 1995. – 21.
Review
For citations:
Kornilov A.V., Alexeev S.A., Bontsevich S.V., Kuncevich M.V., Vykhrystsenka K.S., Matusevich E.A. Characteristic changes in immune resistance in patients with unspecific vertebral infection. Military Medicine. 2026;(2):16-23. (In Russ.) https://doi.org/10.51922/2074-5044.2026.2.16
Views:
14
JATS XML
Email this article 