STRUCTURAL-FUNCTIONAL REMODELING OF MYOCARDIAL IN WOMEN AND MEN WITH SYMPTOMIC AND ASYMPTOMIC HYPERURICEMIA

The results of assessing the influence of the severity of hyperuricemia, age and gender on the forma- tion of pathological structural and functional remodeling of the left ventricular myocardium in patients with gout and asymptomatic hyperuricemia are presented. The key role of the severity of hyperuri- cemia has been established, as well as the association of eccentric hypertrophy with male gender and the onset of gout before 45 years of age, and concentric hypertrophy with moderate asympto- matic hyperuricemia and female gender. Purine metabolism disorders developed in women 10 years later, against the background of high comorbidity. The prospects for early diagnosis of microcrystalline inflammation to initiate uricostatic therapy for asymptomatic hyperuricemia are discussed.

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