FEATURES OF COAGULOGRAM INDICATORS IN PATIENTS WITH VIRAL PNEUMONIA CAUSED BY COVID-19 INFECTION

The article presents the results of a study involving 91 patients with COVID-19-induced pneumonia, confirmed by polymerase chain reaction and computed tomography of the chest organs. Coagulogram parameters were assessed upon hospital admission. Patients were divided into three groups based on the extent of lung involvement: CT1 group – less than 25 % lung involvement, CT2 grouюp – 25-50 % lung involvement, and CT3 group – more than 50 % lung involvement. An increase in D-dimer levels in blood plasma was found in 56.0 % of the overall group of patients, specifically in the CT2 group (92.1 % of patients) and CT3 group (100 % of cases). An increase in fibrinogen levels was also observed only in the CT2 and CT3 groups: 86.8 % of patients and 100 % respectively, while in the overall group, it was noted in 53.8 % of patients. An increase in the prothrombin index was less frequently observed in the CT2 and CT3 groups: 26.3 % in the CT2 group and 100 % of cases in the CT3 group, and in the overall group – 28.6 % of patients. It was concluded that the identified changes in the coagulogram – COVID-19-induced coagulopathy – are an important element in the pathogenesis of the disease and one of the most significant adverse prognostic indicators. These changes are associated with the severity of COVID-19-induced pneumonia and are important for assessing the clinical situation, choosing therapy, and preventing complications.

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