Sarcopenia and Sarcopenic Obesity

Sarcopenia is a progressive generalised skeletal muscle disorder that is associated with increased likelihood of adverse outcomes including falls, fractures, physical disability and mortality. Sarcopenic obesity is a clinical and functional condition characterized by the coexistence of excess fat mass and sarcopenia. In 2018, the European Working Group on Sarcopenia in Older People presented updated data on sarcopenia (EWGSOP2). The European Society for Clinical Nutrition and Metabolism (ESPEN) and the European Association for the Study of Obesity (EASO) launched an initiative to reach expert consensus on a definition and diagnostic criteria for sarcopenic obesity. This article contains the main provisions of the documents and a review of the literature on the mechanisms, diagnosis and clinical significance of sarcopenia and sarcopenic obesity.

1. Cruz-Jentoft A. J., Baeyens J. P., Bauer J. M. et al. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People // Age Ageing. – 2010. – Vol. 39. – P. 412–423.

2. Crus-Jentoft A. E., Bahat G., Bauer J. et al.; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis // Age Ageing. – 2019. – Vol. 48. – P. 16–31.

3. Doninia L. M., Busetto L., Bischoff S. C. et al. Definition and diagnostic criteria for sarcopenic obesity: ESPEN and EASO consensus statement // Obes. Facts. – 2022. – Vol. 15. – P. 321–335.

4. Avgerinou C. Sarcopenia: why i.t matters in general practice // Brit. J. Gen. Pract, April 2020. – Vol. 70(693). – P. 200–201.

5. Papadopoulou S. K. Sarcopenia: A Contemporary health problem among elder adult populations // Nutrients. – 2020. – Vol. 12. – P. 1293.

6. Shaw S. C., Dennison E. M., Cooper C. Epidemiology of sarcopenia: determinants throughout the lifecourse // Calcif. Tissue Int. – 2017. – Vol. 101. – P. 229–247.

7. Vlietstra L., Hendrickx W., Waters D. L. Exercise interventions in healthy older adults with sarcopenia: a systematic review and meta-analysis // Australas J. Ageing. – 2018. – Vol. 37. – P. 169–183.

8. Kamel H. K. Sarcopenia and aging // Nutr. Rev. – 2003. – Vol. 61. – P. 157–167.

9. Bauer J., Biolo G., Cederholm T. et al. Evidencebased recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group // J. Am. Med. Dir. Assoc. – 2013. – Vol. 14. – P. 542–559.

10. Beasley J. M., Shikany J. M., Thomson C. A. The role of dietary protein intake in the prevention of sarcopenia of aging // Nutr. Clin. Pract. – 2013. – Vol. 28. – P. 684–690.

11. Dhillon R. J. S., Hasni S. Pathogenesis and management of sarcopenia // Clin. Geriatr Med. – 2017. – Vol. 33. – P. 17–26.

12. Puthucheary Z. A., Rawal J., Connolly M. M. et al. Acute skeletal muscle wasting in critical illness // JAMA. 2013; 310: 1591–1600.

13. Xia L., Zhao R., Wan Q. et al. Sarcopenia and adverse health-related outcomes: An umbr34-ella review of meta-analyses of observational studies // Cancer Medicine. – 2020. – Vol. 9. – P. 7964–7978.

14. Morley J. E. Sarcopenia: diagnosis and treatment // J. Nutr. Health Aging. – 2008. – Vol. 12. – P. 452–456.

15. Dodds R. M., Granic A., Robinson S. M., Sayer A. A. Sarcopenia, long-term conditions, and multimorbidity: findings from UK Biobank participants // J. Cachexia Sarcopenia Muscle. – 2020. – Vol. 11. – P. 62–68.

16. Byun M. K., Cho E. N., Chang J. et l. Sarcopenia correlates with systemic inflammation in COPD // Int. J. COPD. – 2017. – Vol. 12. – P. 669–675.

17. Tomita Y., Mizukami S., Nishimura T. et al. Association between sarcopenia and respiratory function in elderly orthopedic outpatients // Medicine. – 2022. – Vol. 101. – P. 29 (e29365).

18. Heymsfield S. B., Gonzalez M. C., Lu J. et al. Skeletal muscle mass and quality: evolution of modern measurement concepts in the context of sarcopenia // Proc. Nutr. Soc. – 2015. – Vol. 74. – P. 355–366.

19. Pavasini R., Guralnik J., Brown J. C. et al. Short physical performance battery and all-cause mortality: systematic review and metaanalysis // BMC Med. – 2016. – Vol. 14. P. 215.

20. Dent E., Morley J. E., Cruz-Jentoft A. J. et al. International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management // J. Nutr. Health. Aging. – 2018. – Vol. 22. – P. 1148–1161.