SYNTHETIC ANALOGS OF MELATONIN IN THE COMPLEX PREVENTION OF ULCER DISEASE COMPLICATIONS

We substantiated the expediency of using synthetic analogs of the hormone melatonin in the regimen for the prevention of exacerbations and recurrences of gastric and duodenal ulcers after surgical treatment. Melatonin is used as a drug for management of desynchronosis – the mismatch of daily endogenous biorhythms during periods of increased risk of complications taking into account the patient‘s individual annual cycle. Computer program developed by the authors was used to calculate such periods for the first time.

1. Kambalov, M.N. Riski perforativnyh yazv v individual‘nom godichnom cikle pacientov s yazvennoj bolezn‘yu / M.N. Kambalov // Voen. medicina. – 2017. – № 1 (42). – S. 32–36.

2. Kambalov, M.N. Melatonin i sezonnaya dinamika chastoty perforativnyh / M.N. Kambalov [i dr.] // Voen. medicina. – 2019. – № 3. – S. 53–57.

3. Kambalov, M.N. Rezul‘taty primeneniya sistemy prognozirovaniya v organizacii profilaktiki oslozhnenij gastroduodenal‘nyh yazv / M.N. Kambalov, V.B. Bogdanovich, D.A. Klyujko // Voen. medicina. – 2021. – № 3. – S. 32–37.

4. Kambalov, M.N. Ispol‘zovanie informacionnyh tekhnologij v prognozirovanii i profilaktike oslozhnenij gastroduodenal‘nyh yazv / M.N. Kambalov [i dr.] // Vopr. org. i inform. zdravoohr. – 2019. – № 4. – S. 66–73.

5. Kambalov, M.N. Primenenie informacii o «zonah riska» individual‘nogo godichnogo cikla cheloveka v klinicheskoj medicine / M.N. Kambalov // Voen. medicina. – 2020. – № 4. – S. 100–108.

6. Lobankov, V.M. Mediko-social‘nye aspekty hirurgii yazvennoj bolezni v Belarusi / V.M. Lobankov. Germaniya: Lambert. – 2012. – 260 s.

7. Maksvitis, R.J. Farmacevticheskaya kompoziciya dlya lecheniya yazvennoj bolezni zheludka i/ili 12-perstnoj kishki / R.J. Maksvitis [i dr.] // Patentnyj poisk v RF. [Elektronnyj resurs]. Data dostupa: 09.12.2021. Rezhim dostupa: https://www.freepatent.ru/patents/2448702.

8. Svistunov, A.A. Melatonin i perspektivy primeneniya preparatov melatonina v gastroenterologii / A.A. Svistunov, M.A. Osadchuk, A.M. Osadchuk // Ros zhurn. gastroenterol. gepatol. koloproktol. – 2016. – № 26 (5). – S. 6–12.

9. Sovremennoe sostoyanie problemy lecheniya perforativnoj yazvy zheludka i dvenadcatiperstnoj kishki / V.A. Truhalev., G.I. Gomozov // Sovremennye problemy nauki i obrazovaniya. – 2014. – 2. [Elektronnyj resurs]. Data dostupa: 09.12.2021. Rezhim dostupa: https://science-education.ru/ru/article/view?id=12380.

10. Stewart, B. Global disease burden of conditions requiring emergency surgery / B.Stewart [et all.] // British Journal of Surgery. – 2014. – 101 (1). – R. 9–22.

11. Shaposhnikova, V.I. The temporary genetic program of the endogenous annual cycle of individual development of the person and the phenomenon of its quantization in the course of ontogenesis / V.I Shaposhnikova, V.A.Taymazov, R.P.Narsissov // Uchenye zapiski universiteta imeni P.F. Lesgafta. – 2014. – № 8 (114). – R. 89–201. [Electronic resource]. Data dostupa: 19.10.2021. Rezhim dostupa: DOI: 10.5930/issn.1994-4683.2014.08.114.