Preclinical safety assessment of a new complex local hemostatic agent based on inorganic solts

During the conducted studies of acute toxicity with intraperitoneal administration of a complex local hemostatic agent (CLHA) based on inorganic salts to outbred mice of both sexes, it was established that LD₅₀ for males is 227,8 mg/kg (205,1÷350,5), for females – 262,5 mg/kg (195,8329,2).

The obtained data on the study of acute toxicity on outbred white mice allow us to classify the solution for local application of CLHA to toxicity class IV (low toxic) in accordance with the toxicity classes of substances (modified classification of the Organization for Economic Cooperation and Development OECD).

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