The problem of wound management infected and chronic wounds is still relevant in modern surgery. The number of nosocomial multidrug-resistant strains of bacteria is increasing, which reduces the significance of antibiotic therapy. One of the options for solving this problem is the development of new agents and methods of local treatment, in particular, in the creation of new highly effective wound dressings with antibacterial and reparative properties. Chitosan is a natural biopolymer that has its own antimicrobial activity, hemostatic and sorption effects, the ability to biodegrade and biostimulate repair processes. Due to the amino groups, chitosan can act as a carrier for antiseptic agents such as silver and cerium ions. The article presents the results of an experimental study that evaluated the antibacterial properties of chitosan nanofibers directly modified with silver and cerium ions against standard and hospital strains of microorganisms. The results obtained indicate a high antimicrobial activity of the studied samples and the need for their further study on the model of the wound process.

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