MAGNESIUM: A FORGOTTEN ELEKTROLYTE – DO WE ALWAYS CONSIDER THE NEED FOR CORRECTION?

Magnesium plays an important role in different organs and systems at the cellular and enzymatic levels. It is the second most abundant intracellular cation and the fourth most abundant cation in the body. Despite its importance, it still has not received the needed attention in clinical practice in comparison to other electrolytes like sodium, potassium, and calcium. Hypomagnesemia can lead to many clinical manifestations with some being life-threatening.

1. Swaminathan R. Magnesium metabolism and its disorders. Clin Biochem Rev. 2003 May; 24(2):47-66.

2. Wisit Cheungpasitporn, Charat Thongprayoon, Qi Qian. Dysmagnesemia in Hospitalized Patients: Prevalence and Prognostic Importance. https://doi.org/10.1016/j.mayocp.2015.04.023.

3. Efstratiadis G., Sarigianni M., Gougourelas I. Hypomagnesemia and cardiovascular system. Hippokratia. 2006;10:147–152.

4. Cooper H. A., Domanski M. J., Rosenberg Y., Norman J., Scott J. H., Assmann S. F., McKin-lay S. M., Hochman J. S., Antman E. M., MAGIC Trial Investiga¬ tors Acute ST-segment eleva-tion myocardial infarction and prior stroke: An analysis from the magnesium in coronaries (MAGIC) trial. Am. Heart. J. 2004; 148:1012–1019.

5. Moens A. L., Claeys M. J., Timmermans J. P., Vrints C. J. Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological process. Int. J. Cardiol. 2005;100:179–190.

6. Agus Z. S., Morad M. Modulation of cardiac ion channels by magnesium. Annu. Rev. Phys-iol. 1991;53:299–307.

7. Litonjua A. A. Dietary factors and the development of asthma. Immunol. Allergy Clin. North Am. 2008;28:603–629.

8. Pham P. C., Pham P. M., Pham S. V., Miller J. M., Pham P. T. Hypomagnesemia in patients with type 2 diabetes. Clin. J. Am. Soc. Nephrol. 2007;2: 366–373.

9. Castiglioni S., Cazzaniga A., Albisetti W., Maier J. A. Magnesium and osteoporosis: Current state of knowledge and future research directions. Nutrients. 2013;5:3022–3033.

10. Kotova O. V. Vliyanie stressa na son cheloveka. Zhurnal nevrologii i psihiatrii im. S. S. Korsakova. 2012. № 4 (112). S. 79-82.

11. Altman D., Carroli G., Duley L., Farrell B., Moodley J., Neilson J., Smith D., Magpie Trial Collaborative Group Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The magpie trial: A randomised placebo-controlled trial. Lancet. 2002;359:1877–1890.

12. Ostroumova O. D., Kochetkov A. I., Klepikova M. V. Lekarstvenno-inducirovannyj de-ficit elektrolitov. CHast‘ 2. Lekarstvenno-inducirovannaya gipomagniemiya. RMZH. 2020;12:36-48.

13. O. A. Gromova, I. Yu. Torshin, V. S. Moiseev, M. A. Sorokina. O farmakologicheskih vzaimodejstviyah magniya s antibiotikami i deficite magniya, voznikayushchem v rezul‘-tate antibiotikoterapii. Terapiya, 2017, № 1.