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Dimensional model of schizophrenia in the context of disturbance of smooth follow-up movements of the eyes

Abstract

The article deals with the possible connection between smooth eye tracking movement and symptoms of schizophrenia. The authors draw attention to the fact that the oculomotor function by many scientists is considered as a possible biomarker of the schizophrenic process, or as part of the phenotype of this disease. The temporal parameters of smooth follow-up movement of the eyes in a sample of 198 patients (93 men and 105 women) with paranoid schizophrenia and 46 patients with the risk of first psychosis of males were studied using video-histogram. In patients with the leading disorganization syndrome, a significant disturbance of smooth follow-up movements of the eye was observed at low signal velocities, which suggests a possible conjugated connection of eye tracking mechanisms and disorganization of thinking in schizophrenia. The authors approach the theoretical substantiation of the results obtained from the point of view of the theory of efferent copies.

About the Authors

I. V. Objedkov
УО «Белорусский государственный медицинский университет»
Belarus


M. M. Skugarevskaya
Республиканский научно-практический центр психического здоровья
Belarus


References

1. Kirenskaja, A. V., MjamlinV. V., Novotockij-Vlasov V. Ju., et al. Investigation of the characteristics of saccadic eye movements and the slow negative potentials preceding them in patients with schizophrenia. Rossijskij psihiatricheskij zhurnal. – 2003. – (6): 23–30 (inRussian)

2. Levy, L., Eye Tracking Dysfunction in Schizophrenia: Characterization and Pathophysiology Curr Top Behav Neurosci. – 2010; 4: 311–347.

3. Franco, J. G., J. de Pablo, A. M. Gaviria, E. Sepúlveda, E. Vilella Sociedad Española de Oftalmología, Volume 89, Issue 9, Pages 361–367.

4. Grube, B. S., Bilder, R. M., Goldman, R. S., 1998. Metaanalysis of symptom factors in schizophrenia. Schizophr. Res. 31,113–120.

5. Gureje, O., Aderibigbe, Y. A., Obikoya, O., Three syndromes in schizophrenia: validity in young patients with recent onset of illness. Psychol. Med. 25, 1995; S. 715–725.

6. Tsuang, MT, Lyons MJ, Faraone SV: Clinical phenotypes: problems in diagnosis, in Genetic Research in Psychiatry. Edited by Mendlewicz J, Hippius H. Berlin, Springer, 1992, p 173–187

7. Leboyer, M, Bellivier F, Nosten-Bertrand M, Jouvent R, Pauls D, Mallet J: Psychiatric genetics: search for phenotypes. Trends Neurosci 1998; 21:102–105.

8. Katsanis, J., Iacono, W., 1991. Clinical, neuropsychological, and brain structural correlates of smoothpursuit eye trackingperformance in chronic schizophrenia. Journal of Abnormal Psychology. – S. 526–534.

9. Solomon, C. M., Holzman, P. S., Levin, S., Gale, H. J., 1987. Theassociation between eye-tracking dysfunctions and thought disorder in psychosis. Archives of General Psychiatry 44, 31–35.

10. Liddle, P. F. The symptoms of chronic schizophrenia. Are-examination of the positive_negative dichotomy. BritishJournal of Psychiatry 151, 1987; 145–151.

11. Liddle, P. F., Schizophrenic syndromes, cognitive performance and neurological dysfunction. Psychological Medicine 17, 1987; 49–57.

12. Bilder, R. M., Mukherjee, S., Rider, R. O., Pandurangi, A. K., Symptomatic and neuropsychological correlates ofdefect states. Schizophrenia Bulletin 11. – 1985. – S. 409–419.

13. Andreasen N. C., Olsen S. Negative and positive schizophrenia: definition validation // Arch. Gen. Psychiat. 1982. Vol. 39. P. 789–794.

14. Manual of ICS CHARTRVNG/ENG for Windows XPInstallation and Startup Guide Version 5.0.

15. F. Wuyts and R. BoniverNormative data in ENG and VNGB-ENT, 2008, 4, Suppl. 8, S. 45–47.

16. The function of efference copy signals: Implications for symptoms of schizophrenia L. K. Pynn, J. F. X. De Souza Vision research Volume 76,14 January 2013, P. 124–133.

17. Feinberg I. Efference copy and corollary discharge: implicationsfor thinking and its disorders. Schizophr Bull 1978.-4:S. 636-640.

18. Ford JM, Roach BJ, Mathalon DH. How to assess the corollary discharge in humans using non-invasive neurophysiological methods. Nature Protocols. – 2010. – S. 5:1160-8.

19. Ford JM, Mathalon DH, Heinks T et al. Neurophysiological evidence of corollary discharge dysfunction in schizophrenia. Am J Psychiatry 2001;158. S. 2069–71.

20. Spering M, Montagnini A. Do we track what we see? Common versus independent processing for motion perception and smooth pursuit eye movements: a review. VisionRes. 2011;51:836–852.

21. Kubarko A. I. Vision Volume.2. – Minsk 2009. – P. 147–148.

22. Vit V. V. The structure of the visual system. – Odessa. – 2003. – P. 524.


Review

For citations:


Objedkov I.V., Skugarevskaya M.M. Dimensional model of schizophrenia in the context of disturbance of smooth follow-up movements of the eyes. Military Medicine. 2017;(3):52-58. (In Russ.)

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ISSN 2074-5044 (Print)