The presented review discusses monomodal and polymodal factors of a green nature, responsible for the possible effects of human presence in the forest, park and other green spaces surrounding person. Most of data obtained in recent years mainly international teams of researches using modern diagnostic techniques, and those included in the analysis are conclusive. With regular walks in the forest with a pleasant design, participants of forest therapy programs are noted to mobilize possible psychological and physiological reserves, protective factors of the organism (including cancer killer cells). There is a decrease in the cortisol concentration in the body, psychoemotional stress, validations of autonomic regulation of blood pressure, heart rhythm, and a decrease of the risk of developing non-infectious chronic diseases, including mental, cardiovascular, metabolic and certain types of cancer. Efficacy for individuals of short stay in the forest atmosphere was e[pressed those more, the more deviations of the analyzed parameters of the pre-treatment, and persisted for several days or weeks.
Thus, the further development and wide use of forest therapy can turn it into a strategy of preventive medicine with improvement of somatic, mental health and psychoemotional state of the population of large cities.

1. Berto R., Barbiero G. How the psychological benefits associated with exposure to nature can affect pro-environmental behavior // Ann. Cogn. Sci. – 2017. – No. 1. – P. 16–20.

2. Berto R., Barbiero G., Barbiero P., Senes G. An individual’s connection to nature can affect perceived restorativeness of natural environments. Some observations about biophilia // Behav. Sci. (Basel). – 2018 Mar. – Vol. 8. – No. 3. – 34. – 18 p.

3. Blowman K., Magalhaes M., Lemos M. F. L., et al. Anticancer properties of essential oils and other natural products // Evidance-Based Complem. Altern. Med. – 2018. – Vol. 2018. – Article ID 3149362. – 12 p.

4. Bratman C. N., Hamilson J. P., Daily G. C. The impacts of nature experience on human cognitive function and mental health // Landsc. Urban Plan. – 2015. – Vol. 138. – P. 41–50.

5. Brown S. C., Perrino T., Lombard J., et al. Health disparities in the relationship of neighborhood greenness to mental health outcomes in 249405 U. S. Medicare Beneficiaries // Int. J. Env. Res. Public Health. – 2018. – Vol. 15. – Art. 430.

6. Bykov A. T., Malyarenko T. N., Malyarenko Yu. E. Conscious and unconscious sensory inflows allow effectively control the various functions of human organism // Spanish J. Psychol. – 2006. – No. 2. – P. 201–218.

7. Cohen M. M., Elliot F., Oates L., et al. Do wellness tourists get well? An observational study of multiple dimensions of health and well-being after a week-long retreat // J. Altern. Complement. Med. – 2017. – Vol. 23. – No. 2. – P. 140–148.

8. Cox D. C., Shanahan D. F., Hudson H. L., et al. Doses of neighborhood nature: the benefits for mental health of living with nature // BoiSci. – 2017. – Vol. 67. – P. 147–155.

9. De Keijzer C., Gascon M., Neiuwenhuijsen M. J., Dadvand P. Long-term green space exposure and cognition across the life course: A systematic review // Curr. Environ. Health Rep. – 2016. – Vol. 3. – P. 468–477.

10. Dolling A., Nilsson H., Lundell Y. Stress recovery in forest or handicraft environments – an intervention study // Urban Forestry & Urban Greening. – 2017. – Vol. 27. – P. 162–172.

11. Elliot L. R., White M. P., Taylor A. H., et al. Energy expenditure on recreational visits to different natural environments // Social Sci. & Med. – 2015. – Vol. 139. – P. 53–60.

12. Fabiański M., Brymer E. Enhancing health and wellbeing through immersion in nature: a conceptual perspective combining the stoic and Buddhist traditions // Front. Psychol. – 2017. – Vol. 8. – Art. 1573.

13. Franco L. S., Shanahan D. F., Fuller R. A. A review of the benefits of nature experiences: more than meets the eye // Int. J. Environ. Res. Publ. Health. – 2017. – Vol. 14. – 29 p.

14. Gascon M., Triguero-Mas M., Martinez D., et al. Mental health benefits of long-term exposure to residential green and blue spaces: a systematic review // Int. J. Environ. Res. Public Health. – 2015. – Vol. 12. – P. 4354–4379.

15. Grahn P., Palsdottir A. M., Ottoson J., Jonsdottir I. H. Longer nature-based rehabilitation may contribute to a faster return to work in patients with reactions to severe stress and/ or depression // Int. J. Environ. Res. Public Health. – 2017. – Vol. 14. – No. 11. – pii: E1310.

16. Guan H., Wei H., He X., et al. The three-species-specific effect of forest bathing on perceived anxiety of youngadults in urban forests // Ann. For. Res. – 2017. – Vol. 60. – No. 2. – P. 327–341.

17. Guѐguen N., Stefan J. «Green altruism»; short immersion in natural green environments and helping behavior // Environ. Behavior. – 2016. – Vol. 48. – Issue 2. – P. 324–342.

18. Hansen M. M., Jones R., Tochini K. Shinrin-Yoku (Forest Bathing) and natural therapy: a state-of-the art review // Int. J. Environ. Res. Publ. Health. – 2017. – Vol. 14. – No. 8. – E851.

19. Hart J. Prescribing nature therapy for improving mental health // Alternat. a. Complement. Therapies. – August 2016. – Vol. 22. – No. 42. – P. 161–163.

20. Hartig T., Mitchell R., De Vires S., Frumkin H. Nature and health // Ann. Rev. Publ. Health. – 2014. – Vol. 35. – P. 207–228.

21. Hofmann M., Young C., Binz T. M., et al. Contact to nature benefits health: Mixed effectiveness of different mechanisms // Int. J. Environ. Res. Publ. Health. – 2018. – Vol. 15. – No. 31. – 16 p.

22. Ikei H., Song C., Miyazaki Y. Physiological effects of wood on humans: a review // Wood Sci. – 2017. – Vol. 63. – P. 1–23.

23. James P., Banay R. F., Hart J. E., Laden F. A review of the health benefits of greenness // Curr. Epidemiol. Rep. – 2015. – Vol. 2. – P. 1341–142.

24. Keniger L. E., Gaston K. J., Irvine K. N., Fuller R. A. What are the benefits of interacting with nature? // Intern J. Environ. Res. Public Health. – 2013. – Vol. 10. – P. 913–935.

25. Kensler L. A. W., Uline C. L. Leadership for green schools: sustainability for our children, our communities, and our planet. – Routledge. – Taylor & Francis LTD Group. – New York, London, 2017. – 246 p.

26. Kondo M. C., Jakoby S. F., South E. C. Does spending time outdoors reduce stress? A review of real-timestress response to outdoor environments // Health & Place. – 2018. – Vol. 51. – P. 136–150.

27. Kuo M. How might contact with nature promote human health? Promising mechanisms and a possible central pathway // Front. Psychol. – 2015. – Vol. 6. – Art. 1093. – 7 p.

28. Lee J., Li Q., Tyrvainen L., et al. Nature therapy and preventive medicine. – In: Maddock J., Ed. – Public Health; Social and Behavioral Health. – Intech. – Rijelka, Croatia: 2012. – P. 325–350.

29. Levy B. S., Sidel V. M., Patz J. A. Climate change and collective violence // Annu. Rev. Public Health. – 2017. – Vol. 38. – P. 241–257.

30. Li Q. (Ed.). Forest medicine. – New York: Nova Science Publishers, Inc. – 2012. – P. 55–65.

31. Li Q., Kobayashi M., Inagaki H., et al. A day trip to a forest park increases human natural killer activity and the expression of anti-cancer proteins in male subjects // J. Biol. Regul. Homeost. Agents. – 2010. – Vol. 24. – P. 157–165.

32. Miyazaki Y., Song C., Ikei H. Preventive medical effects of nature therapy and their individual differences // Jpn. J. Physiol. Anthropol. – 2015. – Vol. 20. – P. 19–32.

33. Ohe Y., Ikei H., Song C., Miyazaki Y. Evaluating the relaxation effects of emerging forest-therapy tourism: multidisciplinary approach // Tourism Management. – 2017. – Vol. 62. – P. 322–334.

34. Ohly H., White M. P., Wheeler B. W., et al. A systematic review of the attention restoration potential of exposure to natural environments // J. Toxicol. Environ. Health. Part B. – 2016. – Vol. 19. – P. 305–343.

35. Ratcliffe E., Gatersleben B., Sowden P. T. Bird sounds and their contribution to perceived attention restoration and stress recovery // J. Environ. Psychol. – 2013. – Vol. 36. – P. 221–228.

36. Song C., Ikei H., Lee J., et al. Individual differences in the physiological effects of forest therapy on type A and type B behavioral patterns // J. Physiol. Anthropol. – 2013. – Vol. 32. – No. 14.

37. Song C., Ikei H., Miyazaki Y. Physiological effects of nature therapy: a review of the research in Japan // Int. J. Environ. Res. Publ. Health. – 2016. – Vol. 13. – No. 8. – Art. 781.

38. Sonntag-Östrӧm E., Nordin M., Slunga-Järvholm L., et al. Can rehabilitation in boreal forest help recovery from exhaustion disorder? – The randomized clinical trial ForRest // Scand. J. For. Res. – 2015. – Vol. 30. – P. 732–748.

39. Stigsdotter U. K., Corazon S. S., Sidenius U., et al. Forest design for mental health promotion. – Using perceived sensory dimensions to elicit restorative responses // Landscape a. Urban Planning. – 2017. – Vol. 160. – P. 1–15.

40. Triguero-Mas M., Dadvand P., Cirach M., et al. Natural outdoor environments and mental and physical health: Relationships and mechanisms // Environ. Int. – 2015. – Vol. 77. – P. 35–41.

41. Zijlema W. L., Triguero-Mas M., Smith G., et al. The relationship between natural outdoor environments and cognitive functioning and its mediators // Environ. Res. – 2017. – Vol. 155. – P. 268–275.