The dynamics of intoxication indicators, assessments of the severity of the general condition and symptoms, quality of life in patients with acute purulent rhinosinusitis during treatment
Abstract
In all patients with acute purulent rhinosinusitis (APRS) on the 7th day of treatment, a significant decrease in endogenous intoxication was achieved according to the dynamics of hematological indices. The prognostic parameters of a slower response to the treatment are: the presence of endogenous intoxication and leukocytosis before treatment, baseline estimates of visual analogue scale (VAS) symptoms of rhinorrhea and nasal obstruction, and age over 50 years. The treatment by the 7th day significantly improved the quality of life (QOL) of patients with OGRS, both by assessing the general condition and individual symptoms. A decrease in QOL (VAS > 5) was preserved in 2.9 % of patients according to the general condition, in 4.7 % in hyposmia, in 4.1 % in nasal congestion, in 3.5 % in rhinorrhea and 0 % by pain. Compared with patients who did not have a reduced QOL (VAS 1 < 5) before treatment, in patients with an initially reduced QOL (VAS 1 > 5) on the 7th day of treatment, a clinically significant assessment (VAS2 > 2.3) of the general condition and / or symptoms (with the exception of pain), from 6.4 % to 15.7 % of cases. Thus, the assessment of the general condition by VAS > 5 before treatment is predictive in terms of the likelihood of maintaining the clinical significance of the assessment of the general condition and symptoms (with the exception of pain) by the 7th day of treatment. In the treatment of patients with acute purulent maxillary sinusitis, there was no statistically significant difference in treatment outcomes both in the dynamics of assessments of VAS general condition, individual symptoms and QOL, and in the dynamics of endogenous intoxication indicators between patients who received antibacterial parenteral therapy with ceftriaxone and patients receiving oral amoxicillin / clavulanate.
About the Authors
А. B. PerminovBelarus
A. R. Sakovich
Belarus
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Review
For citations:
Perminov А.B., Sakovich A.R. The dynamics of intoxication indicators, assessments of the severity of the general condition and symptoms, quality of life in patients with acute purulent rhinosinusitis during treatment. Military Medicine. 2019;(4):25-29. (In Russ.)
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