Clinical features of E. faecalis and Enterobacteriaceae and MMP-9 in the colon after elimination of end colostomas
https://doi.org/10.51922/2074-5044.2026.4.31
Abstract
Reconstructive restorative surgery is considered by coloproctologists and patients as the final stage of treatment following obstructive resection of the colon. The relevance of this issue increases every year. This is due to several factors: the growing number of colon surgeries that require a temporary stoma, improved survival rates of patients after cancer treatment, and a shift in the focus of modern medicine toward not only preserving life but also ensuring its high quality. In recent years, evidence has emerged regarding the role of the colonic microbiota in the process of intestinal wall remodeling, which affects the success of reconstructive restorative surgery.
About the Authors
M. Y. ReutovichBelarus
Minsk
B. V. Kirylenka
Belarus
Minsk
A. V. Varabei
Belarus
Minsk
S. A. Kostiuk
Belarus
Minsk
A. G. Dybau
Belarus
Minsk
O. S. Poluyan
Belarus
Minsk
References
1. Claessens, I. The Ostomy Life Study: the everyday challenges faced by people living with a stoma in a snapshot / I. Claessens, R. Probert, C. Tielemans [et al.] // Gastrointestinal Nursing. 2015. Vol. 13, № 5. P. 18–25. DOI: 10.12968/gasn.2015.13.5.18.
2. Changes in the quality of life of adults with an ostomy during the first year after surgery as part of the Best Practice Spotlight Organisation® Programme / B. Martín-Gil, N. Rivas-González, T. Santos-Boya [et al.] // International Wound Journal. 2023. Vol. 21, № 3. DOI: 10.1111/iwj.14456.
3. Hedrick, T. L. AGA Clinical Practice Update on Management of Ostomies: Commentary / T. L. Hedrick, A. Sherman, S. Cohen-Mekelburg, J.Gaidos // Clinical Gastroenterology and Hepatology. 2023. Vol. 21, № 10. P. 2425–2430. DOI: 10.1016/j.cgh.2023.04.035.
4. Life with a stoma across five European countries– a cross-sectional study on long-term rectal cancer survivors / M. Krogsgaard, H. Ø. Kristensen, E. J. B. Furnée [et al.] // Supportive Care in Cancer. 2022. Vol. 30, № 12. P. 9931–9941. DOI: 10.1007/s00520–022–07293-y.
5. Geng, Z. Quality of Life in Chinese Persons Living With an Ostomy / Z. Geng, D. Howell, H. Xu, C. Yuan // Journal of Wound, Ostomy & Continence Nursing. 2017. Vol. 44, № 3. P. 249–256. DOI: 10.1097/WON.0000000000000323.
6. Van de Wall, B. J. M. Conventional and Laparoscopic Reversal of the Hartmann Procedure: a Review of Literature / B. J. M. Van de Wall, W. A. Draaisma, E. S. Schouten [et al.] // Journal of Gastrointestinal Surgery. 2009. Vol. 14, № 4. P. 743–752. DOI: org/10.1007/s11605–009–1084–3.
7. Squire, S. E. Summary for patients: European Hernia Society guidelines on prevention and treatment of parastomal hernias / S. E. Squire, S. A. Antoniou, F. E. Muysoms // Hernia. 2017. Vol. 22, № 1. P. 199–200. DOI: 10.1007/s10029–017–1692-x.
8. Qualitative exploration of home life experiences and care needs among elderly patients with temporary intestinal stomas / S. M. Wang, J. L. Jiang, R. Li [et al.] // World Journal of Gastroenterology. 2024. Vol. 30, № 22. P. 2893–2901. DOI: 10.3748/wjg.v30.i22.2893.
9. Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak / B. D. Shogan, N. Belogortseva, P. M. Luong [et al.] // Science Translational Medicine. 2015. Vol. 7, № 286. DOI: 10.1126/scitranslmed.3010658.
10. Impact of gut microbiota on colorectal anastomotic healing (Review) / Chen Y., Wu N., Yan X. [et al.] // Mol. Clin. Oncol. 2025. Vol. 22, № 6. Art. 52. DOI: 10.3892/mco.2025.2847
11. Lundy, J. A Primer on Wound Healing in Colorectal Surgery in the Age of Bioprosthetic Materials / J. Lundy // Clinics in Colon and Rectal Surgery. 2014. Vol. 27, № 4. P. 125–33. DOI: 10.1055/s-0034–1394086.].
12. Collagen content and types in the intestinal strictures of Crohn’s disease / M. F. Graham, R. F. Diegelmann, C. O. Elson [et al.] // Gastroenterology. 1988. Vol. 94, № 2. P. 257–265. DOI: 10.1016/0016–5085(88)90411–8.
Review
For citations:
Reutovich M.Y., Kirylenka B.V., Varabei A.V., Kostiuk S.A., Dybau A.G., Poluyan O.S. Clinical features of E. faecalis and Enterobacteriaceae and MMP-9 in the colon after elimination of end colostomas. Military Medicine. 2026;(4):31-37. (In Russ.) https://doi.org/10.51922/2074-5044.2026.4.31
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