The influence of the partial pressure of oxygen in the abdominal cavity on the expression of HIF-1α
Abstract
The article presents the results of the effect of hypoxia on the peritoneum. The sample included 10 patients in whom the partial oxygen pressure in the adhesion tissue was recorded intraoperatively by direct oximetry, followed by an immunohistochemical study of HIF-1α expression in it. The study revealed: tissue hypoxia promotes the expression of HIF-1α, affects the development of fibroblasts and, as a result, the production of coarse fibrous tissue in the abdominal cavity. A decrease in hypoxia in the area of surgical intervention will obviously reduce the likelihood of an adhesion process in the abdominal cavity.
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Review
For citations:
Kluyko D.A., Korik V.E., Letkovskaya T.A. The influence of the partial pressure of oxygen in the abdominal cavity on the expression of HIF-1α. Military Medicine. 2020;(1):27-33. (In Russ.)
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