The effect of compulsive overeating disorder on sepsis (review)

Sepsis is one of the most important causes of death in developed countries, where almost 2/3  of the population is obese. Thus, the coexistence of both conditions is becoming a common occurrence in clinical practice, and an increasing number of scientific studies are aimed at studying the potential impact of obesity on sepsis, but their results remain controversial [1].
Compulsive overeating (CED), according to numerous studies, is one of the causes of obesity  in 40 to 70 % of cases, being a trigger factor for this disease. In this regard, there is an increasing need to study obesity in the context of compulsive overeating in critical conditions [2].
The aim of the work: to analyze the data of literary sources touching upon the issues of the influence of obesity (and along with it compulsive overeating) on   sepsis; to emphasize the advantages of a multidisciplinary approach in accompanying people with critical conditions with an assessment of eating disorders, in particular, a history of compulsive overeating.

1. Jagan, N. Sepsis and the obesity paradox: size matters in more than one way / N. Jagan [et al.] // Critical Care Medicine. – 2020. – Vol. 48, № 9. – P. 776–782.

2. Capyak, T. A. Vzglyad na problemu ozhireniya cherez prizmu rasstrojstva pishchevogo povedeniya / T. A. Capyak [i dr.] // Krymskij terapevticheskij zhurnal. – 2020. – № 4. – S. 18–23.

3. Lorene, A. Impact of evidence-based interventions on wound complications after cesarean delivery / A. Lorene [et al.] // Am J Obstet Gynecol. – 2017. – Vol. 217, № 4. – P. 449–458.

4. Lebedev, A. А. Correction of compulsive overeating in rats after maternal deprivation in early age using a new antagonist of OX1 receptors / A. А. Lebedev [et al.] // Psychopharmacology and biological narcology. – 2024. – P. 155–162.

5. Eng, M. Sepsis and obesity: a scoping review of diet-induced obesity murine models / M. Eng [et al.] //Intensive care medicine experimental. – 2024. – Vol. 12, № 1. – P. 15–25.

6. Trivedi, V. Impact of obesity on sepsis mortality: a systematic review / V. Trivedi, C. Bavishi, R. Jean // Journal of critical care. – 2015. – Vol. 30, № 3. – P. 518–524.

7. Gameiro, J. Obesity, acute kidney injury and mortality in patients with sepsis: a cohort analysis / J. Gameiro [et al.] // Renal failure. – 2018. – Vol. 40, № 1. – P. 120–126.

8. Zhou, Q. Impact of body mass index on survival of medical patients with sepsis: a prospective cohort study in a university hospital in China / Q. Zhou [et al.] // BMJ open. – 2018. – Vol. 8, № 9. – P. 219–229.

9. Kalani, C. Sepsis patients in critical care units with obesity: is obesity protective? / C. Kalani [et al.] // Cureus. – 2020. – Vol. 12, № 2. – P. 21–31.

10. Vankrunkelsven, W. Obesity attenuates inflammation, protein catabolism, dyslipidaemia, and muscle weakness during sepsis, independent of leptin / W. Vankrunkelsven [et al.] // Journal of Cachexia, Sarcopenia and Muscle. – 2022. – Vol. 13, № 1. – P. 418–433.

11. Cichon, I. Scrutinizing mechanisms of the ‘Obesity paradox in sepsis’: obesity is accompanied by diminished formation of neutrophil extracellular traps (NETs) due to restricted neutrophil–platelet interactions / I. Cichon [et al.] // Cells. – 2021. – Vol. 10, № 2. – P. 384–390.

12. Van Wyngene, L. Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis. / L. Van Wyngene [et al.] // EMBO Molecular Medicine. – 2020. – Vol. 12, № 2. – P. 113–119.

13. Zeng, Z. The pyruvate dehydrogenase complex in sepsis: metabolic regulation and targeted therapy / Z. Zeng [et al.] // Frontiers in Nutrition. – 2021. – № 8. – P. 78–90.

14. Ghilotti, F. Obesity and risk of infections: results from men and women in the Swedish National March Cohort / F. Ghilotti [et al.] // International Journal of Epidemiology. – 2019. – Vol. 48, № 6. – P. 1783–1794.

15. Ponsford, M. J. Cardiometabolic traits, sepsis, and severe COVID-19: a Mendelian randomization investigation / M. J. Ponsford [et al.] // Circulation. – 2020. – Vol. 142, № 18. – P. 1791–1793.

16. Shubina, S. N. Lechenie kompul’sivnogo pereedaniya (obzor) / S. N. Shubina // Medicinskij zhurnal. – 2024. – № 3. – S. 63–70.