Metabolic associated fatty liver disease as a component of systemic proatherogenic status: results of a comprehensive study

A comprehensive examination of 100 patients with metabolic associated fatty liver disease (MAFLD) was conducted to assess the structure of proatherogenic disorders. It was found that 92 % of patients had grade 2–3 hypertension, 85 % had obesity (BMI 35.1 ± 6.3 kg/m²). Dyslipidemia was detected in 95 % of patients: LDL-C 3.2 mmol/l, TG 2.5 mmol/l, HDL-C 1.2 mmol/l. The average HbA1c level was 8.5 %. When assessing liver fibrosis, F3–F4 stages were identified in 21.2 % of patients. Signs of subclinical atherosclerosis were found in 85 % of patients. Only 18 % of patients received statin therapy. The obtained data indicate the need for a multidisciplinary approach and aggressive correction of risk factors in patients with MAFLD.

1. Ahmedov, V. A. Geneticheskie aspekty formirovaniya nealkogol’noj zhirovoj bolezni pecheni / V. A. Ahmedov, T. I. Melikov // Lechashchij vrach. 2019;8:28–31. https://doi.org/10.26295/OS.2019.70.74.004. [data dostupa: 23.10.2025].

2. Baranov, A. A. Fibroz pecheni pri nealkogol’noj zhirovoj bolezni: klinicheskoe znachenie i metody ocenki / A. A. Baranov, S. V. Kiselyov, E. V. Mel’nikova // Rossijskij zhurnal gastroenterologii, gepatologii, koloproktologii. – 2021. – T. 31, № 2. – S. 45–51.

3. Drapkina, O. M. Epidemiologicheskie osobennosti nealkogol’noj zhirovoj bolezni pecheni v Rossii (Rezul’taty otkrytogo mnogocentrovogo prospektivnogo issledovaniya-nablyudeniya DIREG L 01903) / O. M. Drapkina, V. T. Ivashkin // Rossijskij zhurnal gastroenterologii, gepatologii, koloproktologii. 2014;4:32–38. http://old-gastro-j.ru/files/_2014_4_s4_1417549799.pdf. [data dostupa: 23.10.2025].

4. Mishina, E. E. Nealkogol’naya zhirovaya bolezn’ pecheni: prichina ili sledstvie insulinorezistentnosti? / E. E. Mishina, A. Yu. Majorov, P. O. Bogomolov i dr. // Saharnyj diabet. 2017;20(5):335-342. https://doi.org/10.14341/DM9372. [data dostupa: 23.10.2025].

5. Pal’cev, I. V. Mutacii gena HFE kak faktor riska razvitiya gemohromatoza u bol’nyh hronicheskimi diffuznymi zabolevaniyami pecheni. / I. V. Pal’cev, A. L. Kalinin Problemy zdorov’ya i ekologii. 2010;(4):53–57. https://doi.org/10.51523/2708-6011.2010-7-4-10. [data dostupa: 23.10.2025].

6. Shul’kina, S. G. Znachenie polimorfizma genov MMR12 (rs652483) I PPARG (rs1801282) v formirovanii nealkogol’noj zhirovoj bolezni pecheni u zhenshchin s ozhireniem. / S. G. Shul’kina, P. E. Erbes, E. N. Smirnova // Terapiya. 2022;10:79–88. https://doi.org/10.18565/therapy.2022.10.79–88. [data dostupa: 23.10.2025].

7. Pizzuti, A. A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance / A. Pizzuti, L. Frittitta, A. Argiolas et al. // Diabetes. 1999;48(9):1881–1884. https://doi.org/10.2337/diabetes.48.9.1881. [data dostupa: 23.10.2025].