The analysis of a number of works of domestic and foreign literature devoted to the study of regulatory impact on melatonin hormone, tissue and cellular levels. Has been shown age dynamics of the synthesis of melatonin, has been highlighted certain mechanisms of influence on the reproductive function, antioxidant and immunomodulatory properties. The results of many studies melatonin has confirmed participation in the carcinogenesis process, by changing the proliferative and apoptotic activity, inhibition of telomerase activity.

1. Анисимов, В. Н. Световой режим, риск возникновения рака. Противопухолевое действие мелатонина // РМЖ. — 2015.

2. Анисимов, В. Н. Хронометр жизни // Природа. — 2007. — № 7.

3. Беспятых, А. Ю, В. Я. Бродский, О. В. Бурлакова и др. Мелатонин: теория и практика / Под ред. С. И. Рапопорта, В. И. Голиченкова — М.: ИД «Медпрактика-М», 2009. — 100 с.

4. Гафарова, Е. А. Роль шишковидной железы и ее гормона мелатонина в репродуктивной функции женщины // Практическая медицина. — 06.(11). Акушерство. Гинекология. — ноябрь. — № 15. — 2011.

5. Келадзе, Н. Н., Соболева Е. М., Скоромная Н. Н. Итоги и перспективы изучения физиологических, патогенетических и фармакологических эффектов мелатонина // Здоровье ребенка. — 2010. — 2(23), С. 18—25.

6. Ковальзон, В. М. Мелатонин — без чудес // Природа. — 2004. — № 2. — С. 12—19.

7. Action of melatonin on squamous cell carcinoma and other tumors of the oral cavity// Cutando A., Lopes-Valverde A., D. E. Vicente J. et al / Oncol Lett. 2014 Apr;7(4)

8. Attarchi, M, Darkhi H, Khodarahmian M, Dolati M, Kashanian M, Ghaffari M, Mirzamohammadi E, Mohammadi S: Characteristics of menstrual cycle in shift workers. Glob J Health Sci 2013, 5:163—172.

9. Arushanian, E. B. Pineal hormone melatonin in complex pharmacotherahy of brain and somatic disorders // Recent Pat Endocr Metab Immune Drug Discov. 2011 May; 5(2): 109—23.

10. Bai, J, Dong L, Song Z, Ge H, Cai X, Wang G, Liu P: The role of melatonin as anantioxidant in human lens epithelial cells. Free Radic Res 2013, 47:635—642.

11. Biran, V., Phan Duy A., Decobert F., Bednarek N., Alberti C., Baud O.: Is melatonin ready to be used in preterm infants as a neuroprotectant? Dev Med Child Neurol 2014, 56:717—723.

12. Boczek-Leszczyk, E, Juszczak M: The influence of melatonin on human reproduction. Pol Merkur Lekarski 2007, 23:128—130.

13. Carbajo-Pescador, S, Ordoсez R, Benet M, Jover R, Garcнa-Palomo A, Mauriz J, Gonzбlez-Gallego J: Inhibition of VEGF expression through blockade of Hif1б and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells. Br J Cancer 2013, 109:83—91.

14. Carlomagno, G, Nordio M, Chiu TT, Unfer V: Contribution of myo-inositol and melatonin to human reproduction. Eur J Obstet Gynecol Reprod Biol, 2011, 159:267—272.

15. Circadian rhythms and tumor growth // Greene M. W. / Breast Cancer res Treat/ 2013 Apr; 132(2): 765—71.

16. Galano, A, Tan D, Reiter R: On the free radical scavenging activities of melatonin’s metabolites, AFMK and AMK. J Pineal Res 2013, 54:245—257.

17. Mayo, J, Sainz R, Antoli I, Herrera F, Martin V, Rodriguez C: Melatonin regulation of antioxidant enzyme gene expression. Cell Moll Life Sci 2002, 59:1706—1713.

18. Melatonin enhances thapsigargin-induced apoptosis through reactive oxygen species-mediated upregulation of CCAAT- enhancerbinding protein homologous protein in human renal cancer cells // Min K. J., Kim H. S., Park E. J., Kwon T. K. / J Pineal res. 2012 Aug; 53(1):91—8.

19. Melatonin, immune function and cancer//Srinivasan V., Pandi-Perumal S. R., Brzezinski A. et al./World J Gastroenterol. 2011 Sep 14; 17(34).

20. Melatonin: new application in clinical and veterinary medicine, plant physiology and industry// Reiter R. J., Coto-Montes A., Boga J. A. et al./ Eksp Klin Farmakol. 2011;74(9): 39-45.

21. Melatonin modulation of crosstalk among malignant epithelial, endothelial and adipose cells in breast cancer // Cos S., Alvarez-GarciaV., Gonzalez A. et al. / Oncol Lett. 2014 Aug;8(2):487—492.

22. Melatonin uses in oncology: breast cancer prevention and reduction of the side effects of chemotherapy and radiation // Sanchez-Barcelo E. J., Mediavilla M. D., Alonso-Gonzalez C., Reiter R. J / Bull Exp Biol Med. — 2011. Jul; 151(3):363—5.

23. Melatonin potentiates chemotherapy-induced cytotoxicity and apoptosis in rat pancreatic tumor cells // Uguz A. C., Cig B., Espino J. et al. / Cancer Chemother Pharmacol. 2012 May;69(5): 1213—20.

24. Miyauchi F, Nanjo K, Otsuka K: Effects of night shift on plasma concentrations of melatonin, LH, FSH and prolactin, and menstrual irregularity. Sangyo Igaku 1992, 34:545—550.

25. Nakamura Y, Tamura H, Takayama H, Kato H: Increased endogenous level of melatonin in preovulatory human follicles does not directly influence progesterone production. Fertil Steril 2003, 80:1012—1016.

26. The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis or randomized controlled trials // Wang Y. M., Jin B. Z., Ai F. et al. / Cancer Lett. 2012 May 28; 318(2): 115—23.

27. Overcoming hypoxic-resistance of tumor cells to TRAIL-induced apoptosis through melatonin// Lee Y. J., Lee J. H., Moon J. H. et al./ Int J Mol Sci. 2014 jul 4;15(7).

28. Reiter R, Tan D, Tamura H, Cruz M, Fuentes-Broto L: Clinical relevance of melatonin in ovarian and placental physiology: a review. Gynecol Endocrinol 2014, 30:83—89.

29. Salhab M, Dhorne-Pollet S, Auclair S, Guyader-Joly C, Brisard D, Dalbies-Tran R, Dupont J, Ponsart C, Mermillod P, Uzbekova S: In-vitro maturation of oocytes alters gene expression and signaling pathways in bovine cumulus cells. Mol Reprod Dev 2013, 80:166—182.

30. Shavi Fernando, Luk Rombauts. Мелатонин проливает свет на бесплодие? //Journal of ovarian research.-2014.- Okt; (16).

31. Srinivasan V, Spence W, Pandi-Perumal SR, Zakharia R, Bhatnagar K, Brzezinski A: Melatonin and human reproduction: shedding light on the darkness hormone. Gynecol Endocrinol 2009, 25:779—785.

32. Tamura, H, Takasaki A, Taketani T, Tanabe M, Kizuka F, Lee L, Tamura I, Maekawa R, Aasada H, Yamagata Y, Sugino N: The role of melatonin as an antioxidant in the follicle. J Ovarian Res 2012, 5.

33. Toffol, E, Kalleinen N, Haukka J, Vakkuri O, Partonen T, Polo-Kantola P: Melatonin in perimenopausal and postmenopausal women: associations with mood, sleep, climacteric symptoms, and quality of life. Menopause 2014, 21:493—500.

34. Tomov, B, Popov D, Tomova R, Vladov N, Den Otter W, Krastev Z: Therapeutic response of untreatable hepatocellular carcinoma after application of the immune modulators IL-2, BCG and melatonin. Anticancer Res 2013, 33:4531—4535.

35. Wong, C, Jow G, Kaizaki A, Fan L, Tien L: Melatonin ameliorates brain injury induced by systemic lipopolysaccharide in neonatal rats. Neuroscience 2014, 267:147—156.

36. Zamfir Chiru A. A., Popescu C. R., Gheorghe D. C. Melatonin plays an important role in cancer (tumor growth and metastasis) through different pathways and may have therapeutic significance // J. Med. Life. 2014. Sep. 15;7(3):373-4.