Feature of the expression of laminin in an aortic media in normal and abdominal aortic aneurysm
Abstract
The using a method of immunohistochemistry allowed to determine an expression of laminin in abdominal part of an aortic media in normal in age groups from 1 to 70 years at men and women was determined. The laminin expression in different age groups at men and women was studied and the nature of its changes in normal in different age groups was established. Indicators of the specific area of laminin in aortic media on border from an aneurysm was studied. The comparative analysis of changes of an expression of laminin in normal and in a zone, bordering with aneurism, was carried out. On the basis of the obtained quantitative data the regression analysis was carried out.
References
1. Della Corte A, De Santo LS, Montagnani S et al. Spatial patterns of matrix protein expression in dilated ascending aorta with aortic regurgitation: congenital bicuspid valve versus Marfan's syndrome. 2006 Jan;15(1):20-7.
2. Cotrufo M, De Santo L, Della Corte A, et al. Basal lamina structural alterations in human asymmetric aneu rismatic aorta. Eur J Histochem. 2005;49(4):363-70.
3. Hayward I. P., Bridle K. R., Campbell G. R., et al. Effect of extracellular-matrix proteins on vascular smooth-muscle cell phenotype.Cell Biol.Int.1995;19:839-846
4. Hedin U., Bottger B. A., Forsberg E., et al. Diverse effects of fibronectin and laminin on phenotypic properties of cultured arterial smooth-muscle cells. J Cell Biol 1988;107:307-319.
5. Hedin, U., Roy, J., Tran, P. K., Lundmark, K., and Rahman, A. Control of smooth muscle cell proliferation--the role of the basement membrane. Thromb Haemost 1999; 82 Suppl 1, 23-26.
6. Hedin U., Thyberg J., Roy J., et al. Role of tyrosine kinases in extracellular matrix-mediated modulation of arterial smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol 1997;17:1977-1984.
7. Li X. M., Tsai P., Wieder E. D., et al. Vascular smoothmuscle cells grown on matrigel – a model of the contractile phenotype with decreased activation of mitogen-activated protein-kinase. J Biol Chem 1994;269:19653-19658.
8. Thyberg J., Blomgren K., Roy J., et al. Phenotypic modulation of smooth muscle cells after arterial injury is associated with changes in the distribution of laminin and fibronectin. J Histochem Cytochem 1997;45:837-846.
9. Thyberg J., Hedin U., Sjolund M., et al. Regulation of differentiated properties and proliferation of arterial smooth-muscle cells. Arteriosclerosis 1990;10:966-990.
Review
For citations:
Yuzefovich N.A. Feature of the expression of laminin in an aortic media in normal and abdominal aortic aneurysm. Military Medicine. 2017;(3):130-136. (In Russ.)
Views:
57
JATS XML
Email this article 