The dynamics of hospital morbidity and mortality levels, a general characteristic of clinical observations, methods and results of treatment of acute pancreatitis for the period from January, 1 1997 to December, 31 2016 are presented.
The analyzed period was marked by the growth of the absolute number of patients with acute pancreatitis and necrotizing pancreatitis, as well as the proportion of patients with necrotizing pancreatitis.
The analysis of 1067 cases of acute pancreatitis (804 – the first attack, 263 – repeated attacks) was done in a retrospective observational study. It was determined, that among patients with acute pancreatitis the most numerous group consists of males, young and middle-aged, admitted on a treatment after the alcohol consumption and/or an error in nutrition 24 hours later from the onset of the disease. In etiological structure of acute pancreatitis, the specific gravity of regional circulatory disorders of the hepatopancreatoduodenal zone reaches 8%. The premorbid status of each tenth patient with acute pancreatitis is burdened with CHD, manifested by stenocardia, postinfarction cardiosclerosis or rhythm infringement. The absolute number of patients of elderly and senile age suffers from two and more concomitant diseases.
In 37% of cases of repeated attacks of acute pancreatitis, the disease is characterized by an equal or more severe course with possible lethal outcome.
In sterile (not infected) pancreonecrosis and limited forms of infected pancreonecrosis, treatment should be performed in the option of multicomponent intensive care combined with a minimally invasive surgery. In widespread forms of infected pancreonecrosis, operative management is indicated in the option of «open» drainage with the subsequent performance of repeated programmed sanitations is advised with the purpose to actively monitor all areas of necrotic destruction and infection for the prevention of development of intra-abdominal complications.
The expediency of allocation of compelled and staged modes of interventions in tactics of surgical treatment of necrotizing pancreatitis is substantiated. 
During the analyzed period, the overall mortality from acute pancreatitis has made 8,2%, from necrotizing pancreatitis without differentiation of its clinic-morphological form – 25,9 %, postoperative mortality has made – 47,6%.
By terms (2 weeks before/after) from the disease onset, lethal outcomes from acute pancreatitis are distributed evenly. However, in the structure of causes the proportion of septic conditions is 1,8 times higher than the frequency of aseptic. The cause of the death of each fifth patient died from the necrotizing pancreatitis was hemorrhagic complications.

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