Antibacterial therapy in the complex treatment of widespread peritonitis is important. For effective antimicrobial therapy continuous monitoring of the selected flora is required, allowing you to reduce the percentage of adverse outcomes infections and increase the survival of patients. Range of causative agents of widespread peritonitis and indicators of sensitivity to antibacterial medicines are constantly changing. Therefore, the aim of the investigation was to create an empirical antimicrobial therapy, taking into account differences in the spectrum of pathogens at different levels of integrity of the gastrointestinal tract. As a result of the work modern data were obtained concerning the etiologic structure of causative agents of widespread peritonitis, as well as the range of their resistance to antibacterial drugs, most commonly used in multidisciplinary hospitals of the Republic of Belarus in the treatment of patients with widespread peritonitis. Effective schemes empiric antimicrobial therapy for the most commonly identified pathogens widespread peritonitis at different levels of the integrity of the gastrointestinal tract are offered. The use of effective schemes of empirical antibiotic therapy is a background for improving patient outcomes and growth slowdoun of pathogenic microorganisms resistance development to antimicrobial drugs.

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