According to the World Health Organization, more than a billion diarrheal diseases are registered worldwide each year, with more than half of those occurring in early childhood age. Viral intestinal infections play an important role in infectious diseases in children of different ages. Rotavirus infection refers to the prevalence of viral diarrhea in young children. In acute intestinal infections structure the part of rotavirus infection is about 30–40% (more than 50% amongst intestinal infections with the known agent). In most cases, rotavirus infection ends with a complete recovery of the patient with the appointment of pathogenetic and symptomatic therapy. It is well known that intestinal manifestations are typical for rotavirus infection. However, the fact of generalization of infection with the defeat of various organs and systems (nervous system, liver, kidneys, heart, pancreas) is proved. This article presents a clinical cases and discusses the possibility of damage to the nervous system during rotavirus infection. 

1. Горелов, А. В. Ротавирусная инфекция у детей / А. В. Горелов, Д. В. Усенко // Вопросы современной педиатрии. – № 6, том 8. – С. 78–84.

2. Брико, Н. И. Ротавирусная инфекция: современный взгляд на проблему / Н. И. Брико, А. В. Горелов // Медицинский вестник. – № 14–15. – 2014. – С. 10–11.

3. Acute cerebellitis associated with rotavirus infection / Kato Z. [et. al] // World pediatric journal. – № 9 (1). – 2013. – Р. 87–89.

4. A transient lesion in the corpus callosum during rotavirus infection / Kato Z. [et. al] // Pediatric neurological journal. – № 41. – 2009. – Р.467–469.

5. Clinical and radiological features of rotavirus cerebellitis / Takanashi T. [et. al] // American journal of neuroradiology. – № 31 (9). – 2010. – Р. 1591–95.

6. Nagatomi, T. Rotavirus antigenemia in children with encephalopathy accompanied by rotavirus gastroenteriti / T. Nagatomi, O. Nagatomi // Arch viral journal. – № 150. – 2005. – Р. 1927–31.

7. Ramig, R. Pathogenesis of intestinal and systemic rotavirus infection / R. Ramig // Virol. journal. – № 78. – 2004. – Р. 10213–20.

8. Ramig, R. F. Systemic rotavirus infection / R. Ramig // Expert rev. anti. infect. journal. – 2007. – № 4 (5). – Р. 591–612.

9. Rotavirus and central nervous system symptoms: cause or contaminant? Case reports and review / Lynch M. [et. al] // Clinical infectious diseases journal. – № 33 (7). – 2001. – Р. 932–938.

10. Rotavirus-associated encephalopathy with a reversible splenial lesion / Fukuda S. [et. al] // Pediatr. neurol. journal. – № 40. – 2009. – Р. 133–133.

11. Rotavirus cerebellitis? / Lise E. [et. al] // Clinical infectious diseases journal. – № 8. – 2002. – Р. 130–135.

12. Rotavirus encephalitis and cerebellitis with reversible magnetic resonance signal changes / Mori T. [et. al] // Pediatric int. journal. – № 53 (2). – 2011. – Р. 252–255.

13. Rotavirus Gastroenteritis Associated with Afebrile Convulsion in Children: Clinical Analysis of 40 Cases / Jeng-Juh Hung [et. al] // Chang Gung Med J Vol. – № 9 (26). – 2003. – P. 654–58.

14. Rotavirus meningoencephalitis in a previously healthy child and a review of the literature / Dickey M. [et. al] // Clinical infectious diseases journal. – № 28. – 2009. – Р. 318–321.

15. Systemic manifestation of rotavirus infection in children: A Report of Three Cases / Akcaboy M. [et. al] // Iranian red crescent medical journal. – № 18 (8). – 2016. – Р. 233–235.