Actuality and necessity of using of experimental models of atopic dermatitis on animals and the main problems, associated with its modeling in vivo, were investigated. The existing experimental models were analyzed as well as possible advantages and disadvantages of each of them, depending on the goals and objectives of the study. The model of atopic dermatitis, with a combination of a genetic predisposition with the destruction of the border function of skin (mechanical and chemical disruption) and applications of allergen (with using of repeated sensitization), was learnt in the details. For induction of atopic reaction, depending on assigned tasks of investigation, haptens, foreign proteins (ovalbumin), as well as the most common allergens in the region (for example, on dust mites Dermatophagoides farinae) may be used.

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