The article presents the results of comparison of patients with probable and reliable antiphospholipid syndrome (APS) for clinical manifestations and serological markers of AFS, intra-group features of patients with probable and reliable APS, as well as the content of total vitamin D. the effect of additional administration of cholecalciferol in patients with the presence of antiphospholipid antibodies (APLA) with hypovitaminosis D on the level of total vitamin D and the content of individual AFL in the blood is described. The study included 193 patients: 104 patients with reliable APS, 66 patients with probable AFS and 23 practically healthy person. The Association with systemic lupus erythematosus (SLE) was observed in 25 patients with reliable AFS and 22 patients with probable APS.
The distinctive features of patients with probable AFS were revealed: greater proportion of persons with biological false – positive reaction of Wasserman and lesser proportion with skin lesions. The connection of simultaneous presence of two or more types of APLA with clinical manifestations of APS both in persons with probable and reliable AFS is shown. Presented serological features of patients with reliable APS with a level of total vitamin D < 20,0 ng/ml, Revealed that the lowest content of total vitamin D have the person with the reliable APS associated with SLE than those without SLE and healthy individuals. Shown correction of vitamin D deficiency and reduced level of antibodies to β2-glycoprotein I in AFLA-positive patients who were administered the additional intake of cholecalciferol.

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