Diabetic neuropathy (DN) is one of the most insidious and menacing complications of diabetes mellitus (DM). In the absence of effective methods of treatment of DN (especially clinical forms), based on the principles of evidencebased medicine, successful treatment is possible only at early (preclinical) stages of the disease development. That is why in the last decade the search for low-cost and easily accessible in the wide clinical practice and, at the same time, quite informative screening diagnostic techniques for the subclinical stage of DV has been activated [4].
Reduction of vibration sensitivity is considered one of the early objective signs of sensory neuropathy and occurs long before the manifestation of clinical symptoms. Traditionally, the vibration sensitivity is examined with a tuning fork (usually, 128 Hz). In most cases, to diagnose violations of the vibration sensitivity of a single tuning fork (128 Hz) is not enough. Determination of the vibration sensitivity violation in a wide frequency range (3.15–500 Hz) is possible using the computer pallestesiometry method, in particular using the ANVCH-01 vibration sensitivity analyzer). The research method is based on the up-down algorithm method: an algorithm of psychophysical measurements that allows to determine two sensitivity thresholds (for increasing and decreasing intensity) by presenting a sequence of short-term stimuli of varying intensity to the subject [3]. This method is a qualitative method for studying vibration sensitivity , as well as a highly informative method for diagnosing diabetic neuropathy already at the initial stages of the pathological process. Computerized pallestesiometry with the help of ANVCH-01 is proposed as a modern screening method for diagnosing the subclinical stage of diabetic polyneuropathy with the aim of early initiation of treatment, especially pathogenetically directed.

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