Представлены актуальные сведения по проблеме консервации почечных трансплантатов. Приведены данные о донорах органов, их разновидности. Описаны основные клеточные механизмы при холодовой консервации, отмечены положительные и отрицательные эффекты. Отражены факторы риска и причины возникновения отсроченной функции и отторжения трансплантата почки. Описаны характеристики растворов для холодовой консервации органов.
Цельсиор является внеклеточным раствором. Он был первично разработан для трансплантации сердца. Он содержит высокую концентрацию натрия с гистидином в виде буфера, лактобионат и маннитол для предотвращения отёка и глутатион в качестве антиоксиданта. Раствор сейчас используется при трансплантации сердца, печени, поджелудочной железы и почек.

1. Шумаков, В. И. Трансплантология : рук. / под ред. В. И. Шумакова. – М. : Медицина ; Тула : Репроникс Лтд, 1995. – 391 с.

2. A comparative study of cardiac preservation with Celsior or University of Wisconsin solution with or without prior administration of cardioplegia / N. Boku [et al.] // J Heart Lung Transplant. – 2006. – Vol. 25, № 2. – Р. 219–225.

3. A new perfusate for kidney preservation / Belzer F.O. [et al.] // Transplantation. – Vol. 33, № 3. – Р. 322–323.

4. A comparison of the results of renal transplantation from non-heart-beating, conventional cadaveric, and living donors / M. L. Nicholson [et al.] // Kidney Int. – 2000. – Vol. 58, № 6. – Р. 2585–2591.

5. Association between delayed graft function and allograft and patient survival: a systematic review and metaanalysis / S. G. Yarlagadda [et al.] // Nephrol Dial Transplant. – 2009. – Vol. 24, № 3. – Р. 1039–1047.

6. Carrel, A. The Culture of Whole Organs / A. Carrel, C. A. Lindberg // Science. – Vol. 81, № 2112. – Р. 621–623.

7. Collins, G.M. Simplified 72-hr kidney storage / G. M. Collins, N. A. Halasz // Surg Forum. – Vol. 25, № 0. – Р. 275–277.

8. Cold ischemia is a major determinant of acute rejection and renal graft survival in the modern era of immunosuppression / D. Mikhalski [et al.] // Transplantation. – 2008. – Vol. 85, № 7 Suppl. – Р. 3–9.

9. Cold-induced injury to lung epithelial cells can be inhibited by iron chelators – implications for lung preservation / N. Pizanis [et al.] // Eur J Cardiothorac Surg. – 2011. – Vol. 40, № 4. – Р. 948–955.

10. Cold ischemia induces endothelin gene upregulation in the preserved kidney / S.M. Wilhelm [et al.] // J Surg Res. – 1999. – Vol. 85, № 1. – Р. 101–108.

11. Comparison of histidine-tryptophan-ketoglutarate and University of Wisconsin preservation in renal transplantation / R. J. Lynch [et al.] // Am J Transplant. – 2008. – Vol. 8, № 3. – Р. 567–573.

12. Delayed graft function: risk factors and implications for renal allograft survival / A. O. Ojo [et al.] // Transplantation. – 1997. – Vol. 63, № 7. – Р. 968–974.

13. Efficacy and safety of Celsior preservation fluid in liver transplantation: one-year follow up of a prospective, multicenter, non-randomized study / K. Boudjema [et al.] // Clin Transplant. – 2012. – Vol. 26, № 2. – Р. 199–207.

14. Efficacy of renal preservation: comparative study of Celsior and University of Wisconsin solutions / P. Nunes [et al.] // Transplant Proc. – 2007. – Vol. 39, № 8. – Р. 2478–2479.

15. Evaluation of citrate flushing solution using the isolated perfused rat kidney / P. Jablonski [et al.] // Transplantation. – Vol. 30, № 4. – Р. 239–243.

16. Farag, Y. M. Chronic kidney disease in the Arab world: a call for action / Y. M. Farag, J. A. Kari, A. K. Singh // Nephron. Clin. Pract. – 2012. – Vol. 121, № 3–4. – Р. 120–123.

17. Frequency of hypoglycemia and its significance in chronic kidney disease / M. F. Moen [et al.] // Clin. J. of the Am. Soc. of Nephrol. – 2009. – Vol. 4, № 6. – P. 1121–1127.

18. Fridell, J. A. Clinical experience with histidine-tryptophanketoglutarate solution in abdominal organ preservation: a review of recent literature / J. A. Fridell, R. S. Mangus, A. J. Tector // Clin Transplant. – 2009. – 23 Vol. , № 3. – Р. 305–312.

19. Fuller, B. J. Hypothermic perfusion preservation: the future of organ preservation revisited? / B. J. Fuller, C. Y. Lee // Cryobiology. – 2007. – Vol. 54, № 2. – Р. 129–145.

20. Glomerular hyperfiltration as a nonimmunologic mechanism of progression of chronic renal rejection / A. Barrientos [et al.] // Transplantation. – 1994. – Vol. 57, № 5. – Р. 753–756.

21. Impact of cold ischemia time on renal allograft outcome using kidneys from young donors / D. Hernandez [et al.] // Transpl Int. – 2008. – Vol. 21, № 10. – Р. 955–962.

22. Improved outcomes of renal transplantation from cardiac death donors: a 30-year single center experience / T. Tojimbara [et al.] // Am J Transplant. – 2007. – Vol. 7, № 3. – Р. 609–617.

23. Increased primary non-function in transplanted deceased-donor kidneys flushed with histidine-tryptophan-ketoglutarate solution / R.B. Stevens [et al.] // Am J Transplant. – 2009. – Vol. 9, № 5. – Р. 1055–1062.

24. Influence of preservation method on histopathological lesions of kidney allografts / А. Kwiatkowski [et al.] // Ann Transplant. – 2009. Vol. 14, № 1. Р. 10–13.

25. Kootstra, G. Categories of non-heart-beating donors / G. Kootstra, J. H. Daemen, A. P. Oomen // Transplant Proc. – 1995. – Vol. 27, № 5. – Р. 2893–2894.

26. Kosieradzki, M. Ischemia/reperfusion injury in kidney transplantation: mechanisms and prevention / M. Kosieradzki, W. Rowinski // Transplant. – 2008. – Vol. 40, № 10. – Р. 3279–3288.

27. Lapchinsky, A. G. Recent results of experimental transplantation of preserved limbs and kidneys and possible use of this technique in clinical practice / A.G. Lapchinsky // Ann N Y Acad Sci. – 1960. – Vol. 87. – Р. 539–571.

28. Outcomes of kidneys from donors after cardiac death: implications for allocation and preservation / J.E. Locke // Am J Transplant. – 2007. – Vol. 7, № 7. – Р. 1797–1807.

29. Outcome of renal transplantation in patients over the age of 60: a case-control study / G. Nyberg [et al.] // Nephrol Dial Transplant. – 1995. – Vol. 10, № 1. – Р. 91–94.

30. Opelz, G. Multicenter analysis of kidney preservation / G. Opelz, B. Dohler // Transplantation. – 2007. – Vol. 83, № 3. – Р. 247–253.52. Reperfusion injury in renal transplantation: comparison of LD, HBD and NHBD renal transplants / M. A. Gok [et al.] // Ann Transplant. – 2004. – Vol. 9, № 2. – Р. 33–34.

31. Renal Preservation by Ice-Cooling: an Experimental Study Relating to Kidney Transplantation from Cadavers / R. Calne [et al.] // Br Med J. – Vol. 14, № 2. Р. 651–655.

32. Reperfusion injury in renal transplantation: comparison of LD, HBD and NHBD renal transplants / M. A. Gok [et al.] // Ann Transplant. – 2004. – Vol. 9, № 2. – Р. 33–34.

33. Siedlecki, A. Delayed graft function in the kidney transplant / A. Siedlecki, W. Irish, D. C. Brennan // Am J Transplant. – 2011. – Vol. 11, № 11. – Р. 2279–2296.

34. Taylor, M. J. Current state of hypothermic machine perfusion preservation of organs: The clinical perspective / M. J. Taylor, S. C. Baicu // Cryobiology. – 2010. – Vol. 60, № 3 Suppl. – Р. 20–35.

35. The detrimental effects of delayed graft function in cadaver donor renal transplantation / F. Sanfilippo [et al.] // Transplantation. – 1984. – Vol. 38, № 6. – Р. 643–648.

36. The duration of asystolic ischemia determines the risk of graft failure after circulatory-dead donor kidney transplantation: a Eurotransplant cohort study / L. Heylen [et al.]. // Am J Transplant. – 2018; № 18. – Р. 881.

37. The role of economies of scale in the cost of dialysis across the world: a macroeconomic perspective / A. N. Karopadi [et al.] // Nephrol., Dial., Transplant. – 2013. – Vol. 29, № 4. – P. 885–892.

38. The UNOS renal transplant registry: review of the last decade / M. Andre [et al.] // Clin. Transpl. – 2014. – P. 1–12.

39. Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury / J.L. Koyner [et al.] // Clin J Am Soc Nephrol. – 2010. – Vol. 5, № 12. – Р. 2154–2165.

40. Weinberg, J.M. The cell biology of ischemic renal injury / J.M. Weinberg // Kidney Int. – 1991. – Vol. 39, № 3. – Р. 476–500.